Cellular Respiration and ATP Production — NEET Biology

The breaking of CC bonds of complex organic molecules by oxidation leading to the release of a lot of energy is called cellular respiration. Glucose is the favoured substrate for respiration. Fats and proteins can also be broken down to yield energy. The initial stage of cellular respiration takes place in the cytoplasm. Each glucose molecule is broken through a series of enzyme catalysed reactions into two molecules of pyruvic acid. This process is called glycolysis. The fate of the pyruvate depends on the availability of oxygen and the organism. Under anaerobic conditions either lactic acid fermentation or alcohol fermentation occurs. Fermentation takes place under anaerobic conditions in many prokaryotes, unicellular eukaryotes and in germinating seeds. In eukaryotic organisms aerobic respiration occurs in the presence of oxygen. Pyruvic acid is transported into the mitochondria where it is converted into acetyl CoA with the release of CO₂. Acetyl CoA then enters the tricarboxylic acid pathway or Krebs' cycle operating in the matrix of the mitochondria. NADH + H⁺ and FADH₂ are generated in the Krebs' cycle. The energy in these molecules as well as that in the NADH + H⁺ synthesised during glycolysis are used to synthesise ATP. This is accomplished through a