Class 11 · Cell Cycle and Cell Division

Anaphase: Chromatid Separation — NEET Biology

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At the onset of anaphase, each chromosome arranged at the metaphase plate is split simultaneously and the two daughter chromatids, now referred to as daughter chromosomes of the future daughter nuclei, begin their migration towards the two opposite poles. As each chromosome moves away from the equatorial plate, the centromere of each chromosome remains directed towards the pole and hence at the leading edge, with the arms of the chromosome trailing behind. Thus, anaphase stage is characterised by

🖼️Related NCERT figure: A series of circular diagrams showing the stages of mitosis. The diagrams show: Early Prophase (top) with chromosomes condensing and nuclear envelope intact, Late Prophase (second) with further chromosome condensation and nuclear envelope breaking down, Transition to Metaphase (third) with chromosomes aligning at the cell center with spindle fibers, and Metaphase (bottom) with all chromosomes aligned at the metaphase plate. (Figure 10.2 a and b : A diagrammatic view of stages in mitosis)
NCERT Biology · Class 11 · Chapter 10 · Paragraph 22
How NTA Uses This Concept

During anaphase, sister chromatids separate at the centromere and move toward opposite poles as independent chromosomes. The centromere leads the movement, making the chromosome V-shaped or J-shaped depending on centromere position. Students often confuse anaphase I (homologous chromosomes separate) with anaphase II (sister chromatids separate), or mistakenly think the chromosome arms lead the movement. Remember: centromere always leads, and in mitotic anaphase, sister chromatids (not homologs) separate. This concept is fundamental to understanding chromosome movement mechanics and distinguishing between meiotic stages.

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What is the main function of the spindle fibres during mitosis?

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