At the onset of anaphase, each chromosome arranged at the metaphase plate is split simultaneously and the two daughter chromatids, now referred to as daughter chromosomes of the future daughter nuclei, begin their migration towards the two opposite poles. As each chromosome moves away from the equatorial plate, the centromere of each chromosome remains directed towards the pole and hence at the leading edge, with the arms of the chromosome trailing behind. Thus, anaphase stage is characterised by
During anaphase, sister chromatids separate at the centromere and move toward opposite poles as independent chromosomes. The centromere leads the movement, making the chromosome V-shaped or J-shaped depending on centromere position. Students often confuse anaphase I (homologous chromosomes separate) with anaphase II (sister chromatids separate), or mistakenly think the chromosome arms lead the movement. Remember: centromere always leads, and in mitotic anaphase, sister chromatids (not homologs) separate. This concept is fundamental to understanding chromosome movement mechanics and distinguishing between meiotic stages.
What is the main function of the spindle fibres during mitosis?
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