Class 12 · Molecular Basis of Inheritance

tRNA Structure and Anticodon Specificity — NEET Biology

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For initiation, there is another specific tRNA that is referred to as initiator tRNA. There are no tRNAs for stop codons. In, the secondary structure of tRNA has been depicted that looks like a clover-leaf. In actual structure, the tRNA is a compact molecule which looks like inverted L.

NCERT Biology · Class 12 · Chapter 5 · Paragraph 116
How NTA Uses This Concept

NTA tests whether you understand that tRNA has two critical functional regions: an anticodon loop with bases complementary to mRNA codons, and an amino acid acceptor end that binds specific amino acids. Students often mistake that all tRNAs are identical or confuse which end binds to the codon. The key trap: forgetting that tRNA specificity means each amino acid has its own tRNA, and there's no tRNA for stop codons—these are recognized by release factors instead. Remember: anticodon pairs with codon (base complementarity), amino acid end carries the correct amino acid, and initiator tRNA is special for start codons. The 3D structure is L-shaped, not just the cloverleaf you see in 2D diagrams.

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Against the codon 5′ UAC 3′, what would be the sequence of anticodon on tRNA? (NEET 2022 Phase 2)

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