How do we understand these enzymes? Let us first understand a chemical reaction. Chemical compounds undergo two types of changes. A physical change simply refers to a change in shape without breaking of bonds. This is a physical process. Another physical process is a change in state of matter: when ice melts into water, or when water becomes a vapour. These are also physical processes. However, when bonds are broken and new bonds are formed during transformation, this will be called a chemical reaction. For example:
Arrange the following steps of enzyme action in the correct sequential order as described in the catalytic cycle: P. Formation of a new enzyme-product complex (EP) with altered chemical bonds. Q. Release of products from the active site and regeneration of free enzyme. R. Substrate binding to the active site, fitting into the crevice or pocket. S. Induced fit: Enzyme alters its shape to fit more tightly around the substrate. T. Transformation of substrate structure into a transition state structure while bound to the active site.
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