Enzyme-Substrate Complex & Transition State — NEET Biology
📚 Practice ConceptIt is now understood that the substrate 'S' has to bind the enzyme at its 'active site' within a given cleft or pocket. The substrate has to diffuse towards the 'active site'. There is thus, an obligatory formation of an 'ES' complex. E stands for enzyme. This complex formation is a transient phenomenon. During the state where substrate is bound to the enzyme active site, a new structure of the substrate called transition state structure is formed. Very soon, after the expected bond breaking/making is completed, the product is released from the active site. In other words, the structure of substrate gets transformed into the structure of product(s). The pathway of this transformation must go through the so-called
Arrange the following steps of enzyme action in the correct sequential order as described in the catalytic cycle: P. Formation of a new enzyme-product complex (EP) with altered chemical bonds. Q. Release of products from the active site and regeneration of free enzyme. R. Substrate binding to the active site, fitting into the crevice or pocket. S. Induced fit: Enzyme alters its shape to fit more tightly around the substrate. T. Transformation of substrate structure into a transition state structure while bound to the active site.
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