Enzyme Transition States and Energy — NEET Biology
📚 Practice ConceptThere could be many more 'altered structural states' between the stable substrate and the product. Implicit in this statement is the fact that all other intermediate structural states are unstable. Stability is something related to energy status of the molecule or the structure. Hence, when we look at this pictorially through a graph it looks like something as in
Which of the above statements are correct? S1: Enzymes reduce the difference in potential energy between the stable substrate and the transition state. S2: The catalytic effect of an enzyme is depicted as a downward shift in the energy level of the product (P) relative to the substrate (S) in the energy diagram. S3: Enzymes facilitate the transformation of substrate to product by stabilizing intermediate structural states, making them less unstable. S4: Enzymes do not alter the overall free energy change (ΔG) of a reaction, only the rate at which equilibrium is reached. S5: The increased reaction rate achieved by enzymes is solely due to the prolonged binding of the substrate at the active site.
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