Enzyme-Substrate Complex Formation — NEET Biology
📚 Practice ConceptEach enzyme (E) has a substrate (S) binding site in its molecule so that a highly reactive enzyme-substrate complex (ES) is produced. This complex is short-lived and dissociates into its product(s) P and the unchanged enzyme with an intermediate formation of the enzyme-product complex (EP).
Which of the above statements are correct? S1: The binding of the substrate to the active site induces a conformational change in the enzyme, leading to a tighter fit. S2: The enzyme-product complex (EP) is a short-lived intermediate formed before the release of the product. S3: Enzymes are consumed during the conversion of substrate into product and must be regenerated for subsequent reactions. S4: The active site of an enzyme is always a deep crevice or pocket where the substrate fits perfectly without any induced structural changes. S5: The formation of the enzyme-substrate (ES) complex is an optional step in enzyme catalysis, dependent on specific reaction conditions.
Through deep analysis of NEET and NTA, 88 of 90 questions from the NEET 2026 paper were matched straight from the MedicNEET Biology question bank.
88/90MedicNEET's Biology question bank is built from the same NCERT lines NTA picks repeatedly. Not random MCQs — questions crafted exactly like NTA crafts them.