Only three types of macromolecules, i.e., proteins, nucleic acids and polysaccharides are found in living systems. Lipids, because of their association with membranes separate in the macromolecular fraction. Biomacromolecules are polymers. They are made of building blocks which are different. Proteins are heteropolymers made of amino acids. Nucleic acids (RNA and DNA) are composed of nucleotides. Biomacromolecules have a hierarchy of structures –
Which of the above statements are correct about biomacromolecules? S1: Biomacromolecules are typically found in the acid-insoluble fraction, also known as the retentate, after chemical analysis of living tissue. S2: All biomacromolecules, including lipids, are polymers with molecular weights generally exceeding 10,000 daltons. S3: Proteins, nucleic acids, and polysaccharides are true polymeric biomacromolecules, with their respective monomers being amino acids, nucleotides, and monosaccharides. S4: The acid-soluble pool primarily contains micromolecules with molecular weights ranging from 18 to approximately 800 daltons. S5: Lipids are unique among the compounds of the acid-insoluble fraction because they are not strictly macromolecules but are included due to their association with disrupted cellular membranes. S6: Ribulose bisphosphate Carboxylase-Oxygenase (RuBisCO) is the most abundant protein in the animal world, exemplifying a functional biomacromolecule.
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