Define oxygen dissociation curve. Can you suggest any reason for its sigmoidal pattern?
Assertion (A): Environmental conditions affect haemoglobin’s affinity for oxygen. Reason (R): In tissues, low pO2 and high pCO2 conditions favour dissociation of oxygen from oxyhaemoglobin.
Correct answer: A — If both assertion and reason are true and the reason is the correct explanation of the assertion.
NCERT confirms environmental factors affect oxygen binding - Assertion is true. NCERT states “in the tissues, where low pO2, high pCO2, high H+ concentration and higher temperature exist, the conditions are favourable for dissociation of oxygen from the oxyhaemoglobin.” Reason correctly explains HOW tissue conditions cause oxygen release from haemoglobin, providing the mechanistic basis for the Assertion.
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