Underproduction of hormones by the adrenal cortex alters carbohydrate metabolism causing acute weakness and fatigue leading to a disease called Addison's disease.
In Addison’s disease, why do patients show low blood pressure, muscle weakness and fatigue? A. Adrenal cortex fails to secrete mineralocorticoids → low Na⁺ and water B. Reduced blood volume decreases cardiac output C. Less glucose from gluconeogenesis causes low ATP for muscles D. Respiration centre decreases ventilation rate to compensate
Correct answer: B — a, b and c only
Addison’s disease is adrenal cortical deficiency (Ch-19). It lowers Na⁺ and water (↓BP). Reduced volume ↓ cardiac output (Ch-15). Muscles lack ATP (Ch-17). Respiration may increase, but compensation is incomplete.
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