Hormone Receptor Mechanisms and Signal Transduction — NEET Biology
📚 Practice ConceptHormones which interact with membrane-bound receptors normally do not enter the target cell, but generate second messengers (e.g., cyclic AMP, IP3, Ca++ etc) which in turn regulate cellular metabolism. Hormones which interact with intracellular receptors (e.g., steroid hormones, iodothyronines, etc.) mostly regulate gene expression or chromosome function by the interaction of hormone-receptor complex with the genome. Cumulative biochemical actions result in physiological and developmental effects.
Arrange the following in the correct sequence: 1. HR complex interacts with genome 2. Hormone diffuses into target cell (intracellular access) 3. Gene-expression changes → biochemical/physiological effects 4. Binding to intracellular receptor to form HR complex
View solution & NCERT explanation
Correct answer: C — 2 → 4 → 1 → 3
Steroid and iodothyronine hormones are lipophilic → they diffuse into cells. They bind intracellular (nuclear) receptors forming HR complexes. The complex interacts with the genome. This alters gene expression → biochemical and physiological effects.
What does NCERT say about Hormones which interact with?
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Through deep analysis of NEET and NTA, 176 of the 180 ReNEET 2026 (June 21) questions were already in the MedicNEET question bank before the exam.
176/180MedicNEET's Biology question bank is built from the same NCERT lines NTA picks repeatedly. Not random MCQs — questions crafted exactly like NTA crafts them.