Class 12 · Principles of Inheritance and Variation

Types of Mutations: Point & Frame-Shift — NEET Biology

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In addition to the above, mutation also arise due to change in a single base pair of DNA. This is known as point mutation. A classical example of such mutation is sickle cell anemia. Deletions and insertions of base pairs of DNA, causes frame-shift mutations (see Chapter 5).

NCERT Biology · Class 12 · Chapter 4 · Paragraph 76
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Match the following genetic concepts/disorders with their correct descriptions: Column I (Concept/Disorder) A. Point mutation B. Chromosomal aberration C. UV radiation D. Sickle-cell anaemia E. Phenylketonuria Column II (Description/Characteristic) I. Inborn error of metabolism affecting phenylalanine conversion II. Results from loss or gain of a segment of DNA III. Change in a single base pair of DNA IV. A physical mutagen, classified as non-ionizing V. Caused by a single base substitution in the beta globin chain gene

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