Klinefelter's Syndrome: XXY Karyotype — NEET Biology
✅ Asked in NEET 2025Klinefelter's Syndrome: This genetic disorder is also caused due to the presence of an additional copy of X-chromosome resulting into a karyotype of 47, XXY. Such an individual has overall masculine development, however, the feminine development (development of breast, i.e., Gynaecomastia) is also expressed. Such individuals are sterile.
Klinefelter's Syndrome is caused by an extra X chromosome (47, XXY karyotype), resulting in individuals with masculine development but also feminine features like breast development (gynecomastia). They are sterile and cannot produce offspring. Students often confuse this with Turner's syndrome (45, XO) which affects females, or forget the XXY genotype entirely. The key point: always remember XXY = Klinefelter's (male with female characteristics), while XO = Turner's (female with underdeveloped features). NTA tests whether you can correctly identify the chromosome abnormality and its clinical manifestations—expect questions asking you to match karyotype with syndrome or identify characteristic symptoms from a description.
This paragraph was tested 2 times in NEET.
A male child with XXY genotype will suffer from which disorder? (NEET 2025)
Which of the following statements are correct about Klinefelter’s Syndrome? A. This disorder was first described by Langdon Down (1866). B. Such an individual has overall masculine development. However, the feminine development is also expressed. C. The affected individual is short statured. D. Physical, psychomotor and mental development is retarded. E. Such individuals are sterile. Choose the correct answer from the options given below: (NEET 2022)
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