ATP Yield Assumptions in Cellular Respiration — NEET Biology

Which of the following statements concerning the fate and energy yield of NADH from glycolysis are NOT correct? S1: Under aerobic conditions, the two NADH + H+ molecules produced in glycolysis potentially yield 6 ATP molecules via oxidative phosphorylation. S2: In lactic acid fermentation, the NADH + H+ generated during glycolysis is used to reduce pyruvic acid to lactic acid, regenerating NAD+. S3: The theoretical calculation of 38 ATP from one glucose molecule assumes that all NADH synthesized in glycolysis is transferred into the mitochondria for oxidative phosphorylation. S4: In alcoholic fermentation, the NADH + H+ produced in glycolysis is reoxidized to NAD+ while acetyl CoA is converted to ethanol. S5: The net gain of ATP during fermentation is solely from the direct synthesis during glycolysis, as no oxidative phosphorylation occurs.