Phases of Cell Cycle: The Correct Sequence G1 → S → G2 → M

Biology · Cell Cycle and Cell Division · NEET

The correct sequence of the cell cycle is G1 → S → G2 → M. First three (G1, S, G2) make up interphase (the growth and preparation stage), and M phase is the actual division. Memory hook: "Go Set, Go, Move" (G1 = Grow, S = Synthesise DNA, G2 = Get ready, M = Move/Mitosis).
Cell Cycle Sequence: G1 → S → G2 → MG1Grow, no DNA copySDNA copied 2C→4CG2Prep proteinsMDivisionINTERPHASE (G1 + S + G2) = over 95% of cycleM PHASE
The cell cycle runs G1 → S → G2 → M. The first three phases form interphase (growth and preparation, over 95% of the cycle time); M phase is the short actual division. DNA is copied only in S phase.

Your doubts, answered

Is the S phase before or after G1?

S phase comes after G1. The order is G1 first, then S. In G1 the cell grows but does not copy its DNA. Only in S phase does DNA replication happen. So the cell must finish G1 before it enters S. Never write S before G1.

Why is G2 after S phase and not before?

G2 (Gap 2) is the preparation stage before division. The cell can only prepare to divide after its DNA has been copied, and DNA copying happens in S phase. So S must come first, then G2. In G2 the cell makes proteins needed for mitosis. Order: S → G2 → M.

Does the cell cycle start with M phase or G1?

For counting the sequence, we start with G1. A new cell that has just formed from division enters G1, then goes G1 → S → G2 → M. Because it is a cycle, M is followed again by G1 of the next cell, but the standard NEET answer for the sequence starts at G1: G1 → S → G2 → M.

Which phases make up interphase?

Interphase = G1 + S + G2. These three are the non-dividing growth and preparation phases. M phase (mitosis) is separate and is the actual division. So interphase is the first three of the four, and it takes more than 95% of the total cycle time.

Is G2 part of interphase or part of M phase?

G2 is part of interphase, not M phase. Interphase has three sub-phases: G1, S and G2. The cell is still preparing during G2. Only when G2 ends does the M phase (division) begin. A common trap is to think G2 is the start of mitosis.

⚠️ The NEET trap
G1 → G2 → S → M looks fine because G1, G2 are in number order.
The correct order is G1 → S → G2 → M. DNA is copied in S phase, and this must happen between the two gap phases, not after both. So S sits between G1 and G2.
🧠 Read the letters in order and check where DNA is made.

Real NEET questions

NEET 2019

The correct sequence of phases of cell cycle is:

A · M → G1 → G2 → S
B · G1 → G2 → S → M
C · S → G1 → G2 → M
D · G1 → S → G2 → M
Solution: The cell cycle runs through interphase (G1 → S → G2) followed by the M phase. G1 (growth, no DNA copy) comes before S (DNA synthesis), which comes before G2 (prep for mitosis), which leads into M (division). The other options misplace S or M.
NEET 2024

Following are the stages of cell division: A. Gap 2 phase B. Cytokinesis C. Synthesis phase D. Karyokinesis E. Gap 1 phase. Choose the correct sequence of stages.

A · E-B-D-A-C
B · B-D-E-A-C
C · E-C-A-D-B
D · C-E-D-A-B
Solution: Interphase runs G1 (E) → S (C) → G2 (A). Then M phase begins with karyokinesis (D, nuclear division) and ends with cytokinesis (B, cytoplasm division). So the order is E-C-A-D-B.
ReNEET 2026

The correct sequence of adult cell cycle phases is ________.

A · G1-G2-S-M
B · G1-M-G2-S
C · G1-S-G2-M
D · S-M-G2-G1
Solution: The cycle goes through interphase (G1 → S, where DNA is made → G2) and then the M phase (mitosis). So the correct sequence is G1-S-G2-M.

Solved Cell Cycle and Cell Division NEET PYQs

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Frequently asked

What is the correct sequence of the cell cycle?

G1 → S → G2 → M. G1, S and G2 form interphase; M phase is the actual division. This is the single most asked point in NEET from this chapter.

What does each letter mean?

G1 = Gap 1 (growth, no DNA copy). S = Synthesis (DNA is copied). G2 = Gap 2 (prep and protein-making before division). M = Mitosis (nuclear then cytoplasm division).

How long does each phase take in a typical human cell?

In a 24-hour human cell cycle, interphase (G1 + S + G2) takes about 23 hours (over 95%) and M phase takes less than an hour. Most of the time the cell is in interphase, not dividing.

In which phase is DNA copied?

DNA is copied only in the S (Synthesis) phase. DNA content doubles from 2C to 4C, but the chromosome number stays the same (each chromosome now has two sister chromatids).

Is there a phase after M phase?

Yes. After M phase the new cell enters G1 again, so the cycle repeats. Some cells instead exit into G0 (quiescent stage) and stop dividing until needed.