Tubular Reabsorption in the Nephron

Biology · Excretory Products and Their Elimination · NEET

Tubular reabsorption is the second step of urine formation, where the renal tubule takes back useful substances from the filtrate into the blood. The kidneys filter about 180 litres per day but release only about 1.5 litres of urine, so nearly 99% of the filtrate is reabsorbed. Memory hook: "180 in, 1.5 out — the tubule takes back 99%."
Tubular Reabsorption: Filtrate back into BloodFiltrate~180 L / dayRenal Tubule (PCT)cuboidal + brush borderActive: glucose, aa, Na+Passive: water, wastes~99% reabsorbedBlood(peritubular)Urine: only ~1.5 L
Reabsorption returns useful substances from the filtrate back into blood in the tubule (mainly PCT): glucose, amino acids and Na+ by active transport; water and wastes passively. About 99% of the 180 L filtrate is reabsorbed, leaving only ~1.5 L of urine.

Your doubts, answered

What is the difference between glomerular filtration and tubular reabsorption?

Filtration happens first, at the glomerulus (Bowman's capsule), where blood is pushed through and a filtrate forms. Reabsorption happens next, along the tubule, where useful things (glucose, amino acids, Na+, most water) are taken back from the filtrate into the blood. Filtration removes almost everything from plasma; reabsorption returns nearly 99% of it. So filtration makes the filtrate, reabsorption saves what the body needs.

Is glucose reabsorbed actively or passively?

Glucose, amino acids and Na+ are reabsorbed by ACTIVE transport (they need energy). NCERT is clear on this. In contrast, nitrogenous wastes (like urea) are reabsorbed by PASSIVE transport, and water is also reabsorbed passively in the early parts of the nephron. This active vs passive split is a very common NEET question, so remember: nutrients and sodium = active; wastes and water = passive.

How much of the filtrate is reabsorbed?

Nearly 99% of the filtrate is reabsorbed by the renal tubules. The kidneys form about 180 litres of filtrate per day but the urine released is only about 1.5 litres. Comparing these two numbers tells you that almost all of the filtrate must be taken back into the blood. This 99% figure is a favourite NEET number.

Which part of the nephron reabsorbs the most?

The proximal convoluted tubule (PCT) does the bulk of reabsorption. It reabsorbs nearly all the essential nutrients (glucose, amino acids) and about 70-80% of the electrolytes and water. The PCT is lined by simple cuboidal brush-border epithelium; the brush border (microvilli) increases the surface area for reabsorption. So if a question asks 'main site of reabsorption', the answer is PCT.

Is reabsorption the same as secretion?

No. Reabsorption moves substances FROM the filtrate INTO the blood (taking back useful things). Tubular secretion is the opposite direction: the tubular cells push substances (H+, K+, ammonia) FROM the blood INTO the filtrate to keep blood pH balanced. Both happen in the tubule, but their direction is opposite. See the tubular secretion page for the next step.

⚠️ The NEET trap
Water and urea are reabsorbed actively, while glucose is reabsorbed passively.
Glucose, amino acids and Na+ are reabsorbed ACTIVELY (energy needed); nitrogenous wastes and water are reabsorbed PASSIVELY. NEET repeatedly flips these to trap you.
🧠 Active vs passive: don't swap water and glucose.

Real NEET questions

2016

The part of nephron involved in active reabsorption of sodium is

A · Distal convoluted tubule
B · Proximal convoluted tubule
C · Bowman's capsule
D · Descending limb of Henle's loop
Solution: Active reabsorption of Na+ is a key function of the PCT, which is lined by cuboidal brush-border epithelium that increases surface area. The PCT reabsorbs nearly all essential nutrients and 70-80% of electrolytes and water. Bowman's capsule and the descending limb are not the primary site of active Na+ reabsorption.
2020

Cuboidal epithelium with brush border of microvilli is found in:

A · Proximal convoluted tubule of nephron
B · Eustachian tube
C · Lining of intestine
D · Ducts of salivary glands
Solution: NCERT states the PCT is lined by simple cuboidal brush-border epithelium; the brush border (microvilli) increases the surface area for reabsorption. The intestine has columnar epithelium, so the cuboidal epithelium with a brush border of microvilli is characteristic of the PCT.
2019

Match the following parts of a nephron with their function: (a) Descending limb of Henle's loop (b) Proximal convoluted tubule (c) Ascending limb of Henle's loop (d) Distal convoluted tubule; (i) Reabsorption of salts only (ii) Reabsorption of water only (iii) Conditional reabsorption of sodium ion and water (iv) Reabsorption of ion, water and organic nutrients.

A · (a)-(i), (b)-(iii), (c)-(ii), (d)-(iv)
B · (a)-(ii), (b)-(iv), (c)-(i), (d)-(iii)
C · (a)-(i), (b)-(iv), (c)-(ii), (d)-(iii)
D · (a)-(iv), (b)-(i), (c)-(iii), (d)-(ii)
Solution: Descending limb is permeable to water but almost impermeable to electrolytes, so water only (a-ii). PCT reabsorbs ions, water and organic nutrients (b-iv). Ascending limb is impermeable to water but transports electrolytes, so salts only (c-i). DCT does conditional reabsorption of Na+ and water (d-iii). This gives a-ii, b-iv, c-i, d-iii.

Solved Excretory Products and Their Elimination NEET PYQs

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Frequently asked

What is tubular reabsorption in simple words?

It is the process where the renal tubule takes back useful substances (glucose, amino acids, salts, water) from the filtrate and returns them to the blood, so they are not lost in urine. About 99% of the filtrate is reabsorbed this way.

Why is 99% of the filtrate reabsorbed?

Because the kidneys filter blood in bulk (180 litres/day) to remove wastes quickly, but the body cannot afford to lose that much water, glucose and salt. Reabsorption saves nearly all of it, leaving only about 1.5 litres as urine.

Which substances are reabsorbed actively and which passively?

Glucose, amino acids and Na+ are reabsorbed by active transport. Nitrogenous wastes are reabsorbed passively, and water is reabsorbed passively in the initial segments of the nephron.

What comes after tubular reabsorption?

Tubular secretion. Here the tubular cells secrete H+, K+ and ammonia into the filtrate to balance blood pH and ions. It is the third main step of urine formation.