Difference Between Aerobic and Anaerobic Respiration

Biology · Respiration in Plants · NEET

Aerobic respiration needs oxygen, fully breaks glucose into CO2 and water inside the mitochondria, and releases a large amount of energy (about 36-38 ATP per glucose). Anaerobic respiration (fermentation) happens without oxygen, only partly breaks glucose into lactic acid or ethanol plus CO2 in the cytoplasm, and gives very little energy (net 2 ATP). Memory hook: "Aerobic = Air + All the energy; Anaerobic = No air + Nearly no energy."
GlucoseGlycolysis (cytoplasm)2 Pyruvate (net 2 ATP)+ O2no O2AEROBIC (mitochondria)Krebs cycle + ETSEnd: CO2 + H2O36-38 ATPANAEROBIC (cytoplasm)FermentationEnd: Lactic acid / Ethanol+CO2net 2 ATP
Both paths share glycolysis; with oxygen glucose is fully oxidised in mitochondria (36-38 ATP), without oxygen it is only fermented in the cytoplasm (net 2 ATP).

Your doubts, answered

Is fermentation the same as anaerobic respiration?

In NCERT, yes. NCERT treats fermentation (lactic acid or alcoholic) as the anaerobic breakdown of glucose in many prokaryotes and unicellular eukaryotes like yeast. Both mean glucose is broken down without oxygen and only incompletely. So for NEET, when the question says anaerobic respiration in the context of Chapter 12, it means fermentation.

Why does anaerobic respiration give only 2 ATP while aerobic gives 36-38?

Because anaerobic respiration is incomplete oxidation. Glucose is only split into pyruvate (glycolysis) and then converted to lactic acid or ethanol. The energy stays locked inside these end products. Aerobic respiration fully oxidises glucose to CO2 and water using the Krebs cycle and the electron transport system, so it can release much more energy. NCERT says less than seven per cent of the energy in glucose is released in fermentation.

Which one produces alcohol and which produces lactic acid?

Both are anaerobic. Alcoholic fermentation (by yeast) gives ethanol and CO2. Lactic acid fermentation (by some bacteria and in animal muscle) gives lactic acid and no CO2. Aerobic respiration produces neither; its end products are only CO2 and water. So alcohol and lactic acid are signs of the anaerobic path, not the aerobic one.

Do both aerobic and anaerobic respiration start with glycolysis?

Yes. Glycolysis is common to both. Glucose is first broken into two pyruvate molecules in the cytoplasm, giving a net gain of 2 ATP. After this the paths split: with oxygen the pyruvate enters the mitochondria for aerobic respiration; without oxygen the pyruvate is turned into lactic acid or ethanol (fermentation).

Where in the cell does each type happen?

Glycolysis happens in the cytoplasm for both. The extra fermentation reactions (pyruvate to lactic acid or ethanol) also stay in the cytoplasm, so anaerobic respiration is fully cytoplasmic. Aerobic respiration continues inside the mitochondria, where the Krebs cycle (matrix) and the electron transport system (inner membrane) occur. That is why mitochondria are called the power houses of the cell.

⚠️ The NEET trap
Anaerobic respiration and aerobic respiration both release CO2, so anaerobic respiration must also produce water.
Only aerobic respiration produces water, because water forms when oxygen accepts electrons at the end of the electron transport system. Anaerobic respiration has no oxygen and no ETS, so it makes no water. Also, lactic acid fermentation releases no CO2 at all; only alcoholic fermentation releases CO2.
🧠 No oxygen means no water. Water in respiration is an aerobic-only product.

Real NEET questions

NEET 2022

What amount of energy is released from glucose during lactic acid fermentation?

A · Approximately 15%
B · More than 18%
C · About 10%
D · Less than 7%
Solution: In fermentation (lactic acid or alcoholic) glucose is only incompletely oxidised, so less than seven per cent of the energy stored in glucose is released, and not even all of that is trapped as ATP. This tiny yield is exactly why anaerobic respiration gives only a net 2 ATP, while aerobic respiration releases far more. NCERT Ch 12: less than seven per cent of the energy in glucose is released.

Solved Respiration in Plants NEET PYQs

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Frequently asked

What is the main difference between aerobic and anaerobic respiration?

Aerobic respiration uses oxygen and fully oxidises glucose to CO2 and water, releasing about 36-38 ATP. Anaerobic respiration works without oxygen, only partly breaks glucose into lactic acid or ethanol, and gives a net of just 2 ATP.

How many ATP are produced in aerobic vs anaerobic respiration?

Aerobic respiration gives about 36-38 ATP per glucose molecule. Anaerobic respiration (fermentation) gives a net of only 2 ATP per glucose molecule.

What are the end products of aerobic and anaerobic respiration?

Aerobic respiration produces CO2 and water. Anaerobic respiration produces either lactic acid (lactic acid fermentation) or ethanol and CO2 (alcoholic fermentation).

Which cells carry out anaerobic respiration?

Many prokaryotes and unicellular eukaryotes such as yeast do it, and human muscle cells switch to lactic acid fermentation during hard exercise when oxygen runs short.

Is glycolysis aerobic or anaerobic?

Glycolysis itself does not need oxygen, so it happens in both types. It is the first common step; in anaerobic organisms it is the only respiratory process.