Gene Probe Hybridization for Mutation Detection — NEET Biology
📚 Practice ConceptA single stranded DNA or RNA, tagged with a radioactive molecule (probe) is allowed to hybridise to its complementary DNA in a clone of cells followed by detection using autoradiography. The clone having the mutated gene will hence not appear on the photographic film, because the probe will not have complementarity with the mutated gene.
Assertion (A): Genetic disorders can be detected using molecular probes. Reason (R): Radioactive DNA probes hybridise to complementary sequences and are detected by autoradiography.
View solution & NCERT explanation
Correct answer: A — If both assertion and reason are true and the reason is the correct explanation of the assertion.
Both statements are true from NCERT. NCERT states “A single stranded DNA or RNA, tagged with a radioactive molecule (probe) is allowed to hybridise to its complementary DNA in a clone of cells followed by detection using autoradiography.” The Reason explains the molecular mechanism HOW genetic detection (Assertion) works - through probe hybridisation and autoradiographic detection.
What does NCERT say about single stranded DNA or?
Has this concept appeared in NEET?
Which chapter is this from?
Through deep analysis of NEET and NTA, 88 of 90 questions from the NEET 2026 paper were matched straight from the MedicNEET Biology question bank.
88/90MedicNEET's Biology question bank is built from the same NCERT lines NTA picks repeatedly. Not random MCQs — questions crafted exactly like NTA crafts them.