Lipid Synthesis in SER — NEET Biology
✅ Asked in NEET 2018Which of the following events does not occur in rough endoplasmic reticulum? (NEET 2018)
Which of the following events does not occur in rough endoplasmic reticulum? (NEET 2018)
Answer & NCERT explanation
Correct answer: D — Phospholipid synthesis
Phospholipid synthesis does NOT occur in rough ER but in smooth ER. According to NCERT, RER is involved in protein folding, protein glycosylation (adding carbohydrates), and cleavage of signal peptides. SER is specialized for lipid synthesis including phospholipids, steroids, and other lipids. This is a key functional difference between rough and smooth ER.
Read more NCERT concept on the PYQ
The smooth endoplasmic reticulum is the major site for synthesis of lipid. In animal cells lipid-like steroidal hormones are synthesised in SER.
The NTA specifically tests whether students know that the smooth endoplasmic reticulum (SER), NOT the rough endoplasmic reticulum (RER), is the major site for lipid synthesis. RER is studded with ribosomes and synthesizes proteins, while SER lacks ribosomes and handles lipid and steroid hormone synthesis. Students commonly confuse the two organelles because they focus on remembering that RER makes proteins without clearly distinguishing SER's unique role in lipid metabolism. To score correctly: RER = protein synthesis; SER = lipid and steroid hormone synthesis. This distinction is fundamental to cell biology and appears frequently in NEET questions testing organelle structure-function relationships.
What does NCERT say about smooth endoplasmic reticulum major?
Has this concept appeared in NEET?
Which chapter is this from?
Through deep analysis of NEET and NTA, 88 of 90 questions from the NEET 2026 paper were matched straight from the MedicNEET Biology question bank.
88/90MedicNEET's Biology question bank is built from the same NCERT lines NTA picks repeatedly. Not random MCQs — questions crafted exactly like NTA crafts them.