Glucocorticoids stimulate gluconeogenesis, lipolysis and proteolysis; and inhibit cellular uptake and utilisation of amino acids. Cortisol is also involved in maintaining the cardio-vascular system as well as the kidney functions. Glucocorticoids, particularly cortisol, produces anti-inflammatory reactions and suppresses the immune response. Cortisol stimulates the RBC production. Aldosterone acts mainly at the renal tubules and stimulates the reabsorption of Na+ and water and excretion of K+ and phosphate ions. Thus, aldosterone helps in the maintenance of electrolytes, body fluid volume, osmotic pressure and blood pressure. Small amounts of androgenic steroids are also secreted by the adrenal cortex which play a role in the growth of axial hair, pubic hair and facial hair during puberty.
NTA focuses on aldosterone's specific role at the kidney's renal tubules to regulate electrolyte balance, NOT blood glucose. Students often confuse aldosterone with glucocorticoids (cortisol) because both are adrenal hormones; however, cortisol controls glucose metabolism while aldosterone controls Na⁺ reabsorption and K⁺ excretion. The key distinction: aldosterone maintains electrolytes, body fluid volume, and blood pressure through direct action on renal tubules. To avoid mistakes, remember that whenever a question asks about kidney electrolyte regulation or sodium-potassium balance, the answer is aldosterone, not cortisol. This concept appears repeatedly because it's a classic hormone-target tissue pairing that tests whether you understand hormone specificity.
This paragraph was tested 2 times in NEET.
Which one of the following hormones is not involved in sugar metabolism? (NEET 2022)
Which of the following hormones acts to conserve sodium ions in the body? (NEET 2020)
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