Graft Rejection and Tissue Matching — NEET Biology
✅ Asked in NEET 2024Tissue matching, blood group matching are essential before undertaking any graft/transplant and even after this the patient has to take immuno-suppressants all his/her life. The body is able to differentiate 'self' and 'nonself' and the cell-mediated immune response is responsible for the graft rejection.
NTA tests whether students understand why transplants are rejected and how to prevent it. The core concept: the body's cell-mediated immune response recognizes grafts as 'nonself' and attacks them, causing rejection. The key trap: students often think blood group matching alone is sufficient—but tissue matching is equally critical. What to remember: tissue compatibility, blood group matching, AND lifelong immunosuppressants are ALL necessary for successful transplants. The body constantly distinguishes 'self' from 'nonself' through immune mechanisms. Expect questions on why rejection occurs, what prevents it, or consequences of skipping any step in matching protocols.
This paragraph was tested 4 times in NEET.
Given below are two statements: One is labelled as Assertion (A) and the other is labelled as Reason (R). (NEET 2024) Assertion (A): Some human organs like the liver and kidney fail to function normally, and transplantation is the only remedy to enable the patient to live a normal life. Reason (R): Tissue matching and blood group matching are essential before undertaking any transplant, and the patient has to take immunosuppressants thereafter. In light of the above statements, choose the correct answer from the options given below:
Which of the following reasons is mainly responsible for graft rejection in transplantation of organs? (NEET 2022 Phase 2)
Which of the following immune response is responsible for the rejection of kidney grafts? (NEET 2019)
Transplantation of tissues/organs fails often due to non-acceptance by the patient’s body. Which type of immune response is responsible for such rejections? (NEET 2017)
Through deep analysis of NEET and NTA, 88 of 90 questions from the NEET 2026 paper were matched straight from the MedicNEET Biology question bank.
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