Class 12 · Human Health and Diseases

Carcinogens and Cellular Oncogenes — NEET Biology

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Causes of cancer: Transformation of normal cells into cancerous neoplastic cells may be induced by physical, chemical or biological agents. These agents are called carcinogens. Ionising radiations like X-rays and gamma rays and non-ionizing radiations like UV cause DNA damage leading to neoplastic transformation. The chemical carcinogens present in tobacco smoke have been identified as a major cause of lung cancer. Cancer causing viruses called oncogenic viruses have genes called viral oncogenes. Furthermore, several genes called cellular oncogenes (c-onc) or proto oncogenes have been identified in normal cells which, when activated under certain conditions, could lead to oncogenic transformation of the cells.

NCERT Biology · Class 12 · Chapter 7 · Paragraph 58
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QuestionPractice Question

Q7. Match the Column Column I (Gene Type) A. Proto-oncogene B. Viral oncogene C. Tumour suppressor gene Column II (Effect) i. Introduced by oncogenic viruses ii. Causes cancer when abnormally activated iii. Normally inhibits cell proliferation

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Correct answer: B A–ii, B–i, C–iii

Each gene class is linked with its function or abnormal effect on cell cycle.

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Causes of cancer: Transformation of normal cells into cancerous neoplastic cells may be induced by physical, chemical or biological agents. These agents are called carcinogens.
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Human Health and Diseases, Class 12 NCERT Biology.

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