Carcinogens and Cellular Oncogenes — NEET Biology
📚 Practice ConceptCauses of cancer: Transformation of normal cells into cancerous neoplastic cells may be induced by physical, chemical or biological agents. These agents are called carcinogens. Ionising radiations like X-rays and gamma rays and non-ionizing radiations like UV cause DNA damage leading to neoplastic transformation. The chemical carcinogens present in tobacco smoke have been identified as a major cause of lung cancer. Cancer causing viruses called oncogenic viruses have genes called viral oncogenes. Furthermore, several genes called cellular oncogenes (c-onc) or proto oncogenes have been identified in normal cells which, when activated under certain conditions, could lead to oncogenic transformation of the cells.
Q7. Match the Column Column I (Gene Type) A. Proto-oncogene B. Viral oncogene C. Tumour suppressor gene Column II (Effect) i. Introduced by oncogenic viruses ii. Causes cancer when abnormally activated iii. Normally inhibits cell proliferation
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