The salient features of the Double-helix structure of DNA are as follows:
Which of the following statements are correct regarding the structural features of the DNA double helix that contribute to its stability and overall architecture? S1: The two polynucleotide chains in a DNA molecule are coiled in a left-handed fashion. S2: Hydrogen bonds between complementary base pairs are crucial, with Adenine forming three H-bonds with Thymine and Guanine forming two H-bonds with Cytosine. S3: The backbone of the DNA double helix is formed by alternating sugar and phosphate groups, with the nitrogenous bases projecting inwards. S4: Stacking interactions between successive base pairs in the double helix, in addition to hydrogen bonds, confer significant stability. S5: The anti-parallel polarity of the two DNA strands means that if one strand has a 5'→3' orientation, the other has a 3'→5' orientation.
Correct answer: D — S3, S4 and S5 are correct
The core concept revolves around the defining structural features of the DNA double helix and the forces that maintain its stability. S1: This statement is not correct. The NCERT states that 'The two chains are coiled in a right-handed fashion,' not left-handed. S2: This statement is not correct. Adenine forms 'two hydrogen bonds with Thymine' and Guanine forms 'three H-bonds' with Cytosine. The numbers are reversed in the statement. S3: This statement is correct. The backbone is constituted by sugar-phosphate, and bases project inside. S4: This statement is correct. Stacking of base pairs, along with H-bonds, provides stability to the helical structure. S5: This statement is correct. The anti-parallel polarity is a key feature of the DNA double helix. Therefore, statements S3, S4, and S5 are correct. Options A, B, and C contain incorrect statements S1 or S2 or both. The correct option is D as it correctly identifies the true statements about the DNA double helix structure.
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