Chromatin Packaging Proteins — NEET Biology
✅ Asked in NEET 2017Association of histone H1 with nucleosome indicates: (NEET 2017)
Association of histone H1 with nucleosome indicates: (NEET 2017)
Answer & NCERT explanation
Correct answer: B — Condensed DNA as chromatin fibre
Histone H1 is the linker histone that binds to nucleosome and linker DNA, causing chromatin condensation into 30nm fiber. Its association indicates higher-order chromatin structure formation and DNA condensation. H1 is not directly involved in replication, transcription, or DNA exposure - these processes require chromatin relaxation and H1 dissociation.
Read more NCERT concept on the PYQ
The beads-on-string structure in chromatin is packaged to form chromatin fibers that are further coiled and condensed at metaphase stage of cell division to form chromosomes. The packaging of chromatin at higher level requires additional set of proteins that collectively are referred to as
NTA tests understanding of how chromatin's beads-on-string structure is progressively packaged into higher-order structures using additional proteins beyond histones. The core concept is that non-histone proteins (like condensins and topoisomerases) are essential for coiling and condensing chromatin fibers into visible chromosomes during cell division. Students often confuse histone proteins (which form nucleosomes) with the additional packaging proteins, missing that multiple protein sets work sequentially. Remember: histones create nucleosomes; additional non-histone proteins compress these further into chromatin fibers and chromosomes. This concept remains testable because understanding chromatin organization is fundamental to grasping gene regulation and chromosome structure in eukaryotes.
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