Griffith's Transformation Experiment — NEET Biology
📚 Practice ConceptHe concluded that the R strain bacteria had somehow been transformed by the heat-killed S strain bacteria. Some 'transforming principle', transferred from the heat-killed S strain, had enabled the R strain to synthesise a smooth polysaccharide coat and become virulent. This must be due to the transfer of the genetic material. However, the biochemical nature of genetic material was not defined from his experiments.
Which of the following statements are NOT correct concerning Frederick Griffith's experiment and its subsequent biochemical characterization? S1. Griffith's experiment clearly demonstrated that a 'transforming principle' was transferred from heat-killed S strain to live R strain bacteria. S2. The R strain bacteria, upon transformation, lost their ability to synthesize a smooth polysaccharide coat. S3. The main limitation of Griffith's experiment was its inability to identify the specific chemical nature of the genetic material. S4. Avery, MacLeod, and McCarty utilized protein-digesting enzymes (proteases) which inhibited transformation. S5. The transforming principle in Griffith's experiment was found to be stable enough not to be destroyed by heat. S6. Griffith's findings directly contradicted Mendel's principles of inheritance.
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