Class 12 · Molecular Basis of Inheritance

Semiconservative DNA Replication — NEET Biology

✅ Asked in NEET 2018
📖 NCERT Source

It is now proven that DNA replicates semiconservatively. It was shown first in Escherichia coli and subsequently in higher organisms, such as plants

NCERT Biology · Class 12 · Chapter 5 · Paragraph 55
How NTA Uses This Concept

Semiconservative replication means each new DNA molecule contains one original (parental) strand and one newly synthesized strand. NTA tests whether students know this was first demonstrated in E. coli by Meselson and Stahl using nitrogen isotopes. The common mistake is confusing semiconservative replication with conservative (both strands together) or dispersive replication. Students often forget that NEET questions ask specifically which organism proved this mechanism first — always E. coli, not plants or humans. Remember: Meselson-Stahl experiment with heavy nitrogen (N-15) and light nitrogen (N-14) in bacteria remains the gold standard proof for NEET.

Solve This NEET Question
QuestionNEET 2018

Semi-conservative DNA replication was first shown in a: (NEET 2018)

Through deep analysis of NEET and NTA, 88 of 90 questions from the NEET 2026 paper were matched straight from the MedicNEET Biology question bank.

88/90
of the NEET 2026 Biology paper matched from the MedicNEET question bank

MedicNEET's Biology question bank is built from the same NCERT lines NTA picks repeatedly. Not random MCQs — questions crafted exactly like NTA crafts them.

88 of 90 NEET 2026 Biology questions traced to MedicNEET10,000+ Biology questionsHindi + English
Free to start · Hindi + English · 10,000+ questions · NEET 2026 pattern
Related Concepts from Molecular Basis of Inheritance
📘Practice all 84 NEET PYQs from Molecular Basis of Inheritance