Using a Punnett Square, workout the distribution of phenotypic features in the first filial generation after a cross between a homozygous female and a heterozygous male for a single locus.
In a cross between a male and female, both heterozygous for the sickle cell anaemia gene, what percentage of the progeny will be diseased? (NEET 2021)
Correct answer: C — 25%
Parents: HbA HbS × HbA HbS Punnett square: HbA HbA → Normal HbA HbS → Carrier HbS HbS → Sickle cell disease Genotypic ratio: 1 (Normal) : 2 (Carrier) : 1 (Diseased) So, 1 out of 4 (25%) progeny will be diseased (HbS HbS).
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