Class 12 · Principles of Inheritance and Variation

Punnett Square: Homozygous × Heterozygous — NEET Biology

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Using a Punnett Square, workout the distribution of phenotypic features in the first filial generation after a cross between a homozygous female and a heterozygous male for a single locus.

NCERT Biology · Class 12 · Chapter 4 · Paragraph 108
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In a cross between a male and female, both heterozygous for the sickle cell anaemia gene, what percentage of the progeny will be diseased? (NEET 2021)

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Correct answer: C 25%

Parents: HbA HbS × HbA HbS Punnett square: HbA HbA → Normal HbA HbS → Carrier HbS HbS → Sickle cell disease Genotypic ratio: 1 (Normal) : 2 (Carrier) : 1 (Diseased) So, 1 out of 4 (25%) progeny will be diseased (HbS HbS).

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Using a Punnett Square, workout the distribution of phenotypic features in the first filial generation after a cross between a homozygous female and a heterozygous male for a single locus.
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Principles of Inheritance and Variation, Class 12 NCERT Biology.

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