Chromosomal Disorders: Trisomy & Monosomy — NEET Biology
📚 Practice ConceptThese situations are known as trisomy or monosomy of a chromosome, respectively. Such a situation leads to very serious consequences in the individual. Down's syndrome, Turner's syndrome, Klinefelter's syndrome are common examples of chromosomal disorders.
Match the following genetic disorders with their genetic basis/karyotype and key symptoms/characteristics: Column I (Disorder) A. Down’s syndrome B. Klinefelter’s syndrome C. Turner’s syndrome D. Thalassemia E. Sickle-cell anaemia Column II (Genetic Basis/Karyotype) I. Autosome-linked recessive trait with GAG to GUG mutation II. Trisomy of chromosome 21 III. 47, XXY IV. 45, X0 V. Autosome-linked recessive trait with reduced globin chain synthesis Column III (Key Symptom/Characteristic) P. Sterility, rudimentary ovaries, lack of secondary sexual characters Q. Mental retardation, short stature, partially open mouth R. Gynaecomastia, overall masculine development S. Qualitative problem of incorrect globin functioning, sickle-shaped RBCs T. Quantitative problem of too few globin molecules, anaemia Choose the correct match from the options given below:
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