Conduction Pathway of Action Potential in the Heart

Biology · Body Fluids and Circulation · NEET

The action potential in the heart follows one fixed path: SA node (SAN) to AV node (AVN) to AV bundle (bundle of His) to bundle branches (right and left) to Purkinje fibres, which spread it through the ventricle walls. Memory hook: "Sarah And Alex Bought Purple" = SAN, AVN, AV bundle, Bundle branches, Purkinje. NEET tests this exact order and the small 0.1-second delay at the AVN.
Conduction Pathway of the HeartSANAVNAV bundlebundle branchesPurkinje fibres1. SAN (start)2. AVN (0.1s delay)3. AV bundle (His)4. Bundle branches5. Purkinje fibresE-C-A-D-B (2024)
The impulse travels SAN to AVN to AV bundle (bundle of His) to right and left bundle branches to Purkinje fibres, matching the NEET 2024 order E-C-A-D-B. The AVN adds a 0.1 second delay so the atria empty before the ventricles contract.

Your doubts, answered

What is the exact conduction sequence NEET wants?

SA node (SAN) generates the impulse, then it passes to the AV node (AVN), then to the AV bundle (bundle of His), which splits into the right and left bundle branches, and finally the Purkinje fibres carry it through the whole ventricular muscle. In NEET 2024 the letter order was E-C-A-D-B. Learn it forward and never break the chain.

Why does the AV node delay the impulse by about 0.1 second?

The AVN holds the signal for roughly 0.1 second so that atrial contraction (atrial systole) finishes first. This lets the atria empty their blood completely into the ventricles before the ventricles contract. NEET 2019 tested exactly this: the delay 'allows the atria to empty completely'.

Is the AV bundle the same as the bundle of His?

Yes. NCERT calls it the 'atrio-ventricular bundle (AV bundle)', and it is the same structure as the bundle of His. It continues from the AVN, passes through the atrio-ventricular septum, and then divides into the right and left bundle branches. Do not treat AV bundle and bundle of His as two different steps.

Do Purkinje fibres come before or after the bundle branches?

After. The order is bundle branches first, then Purkinje fibres. The bundle branches run down the sides of the ventricles, and the Purkinje fibres are the fine terminal branches that spread the impulse into the ventricular muscle to cause ventricular systole. Reversing these two is the most common mistake.

Where does the action potential of the heart begin and why?

It begins at the SA node in the upper right corner of the right atrium. The SAN is the pacemaker because it generates the maximum action potentials (about 70-75 per minute) and depolarises fastest, so it sets the rhythm for the whole heart.

⚠️ The NEET trap
Purkinje fibres receive the impulse straight from the AV bundle, before the bundle branches.
The AV bundle first divides into the right and left bundle branches, and only then do the Purkinje fibres spread the impulse through the ventricular muscle. Order: AV bundle to bundle branches to Purkinje fibres.
🧠 Bundle branches BRANCH first, Purkinje POKE into muscle last.

Real NEET questions

2024

Following are the stages of pathway for conduction of an action potential through the heart: A. AV bundle, B. Purkinje fibres, C. AV node, D. Bundle branches, E. SA node. Choose the correct sequence of pathway.

A · A-E-C-B-D
B · B-D-E-C-A
C · E-A-D-B-C
D · E-C-A-D-B
Solution: The impulse starts at the SA node (E), goes to the AV node (C), then the AV bundle (A), which divides into the right and left bundle branches (D), and finally spreads through the ventricular muscle via the Purkinje fibres (B). The order is E-C-A-D-B.
2019

A specialised nodal tissue embedded in the lower corner of the right atrium, close to the atrio-ventricular septum, delays the spreading of impulses to the heart apex for about 0.1 sec. The delay allows:

A · blood to enter aorta.
B · the ventricles to empty completely.
C · blood to enter pulmonary arteries.
D · the atria to empty completely.
Solution: The tissue is the AV node (AVN). Its short 0.1 second delay lets atrial systole finish first, so the atria empty their blood completely into the ventricles before the ventricles contract.

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Frequently asked

What is the full conduction pathway of the heart?

SA node to AV node to AV bundle (bundle of His) to right and left bundle branches to Purkinje fibres, which then spread the impulse across the ventricle walls.

Why is the SA node called the pacemaker?

Because it generates the most action potentials, about 70-75 per minute, and depolarises fastest, so it sets the heartbeat rhythm for the whole heart.

How long is the AV node delay and why does it matter?

About 0.1 second. This short pause lets the atria finish contracting and empty fully into the ventricles before the ventricles contract.

Are AV bundle and bundle of His different?

No. NCERT uses 'AV bundle', which is the same structure as the bundle of His. Count it as one step in the pathway.

What do Purkinje fibres do?

They are the fine terminal fibres that carry the impulse into the ventricular muscle, causing the ventricles to contract (ventricular systole).