Karyokinesis vs Cytokinesis: Nuclear vs Cytoplasm Division

Biology · Cell Cycle and Cell Division · NEET

Karyokinesis is the division of the nucleus (the chromosomes separate into two sets). Cytokinesis is the division of the cytoplasm that splits one cell into two daughter cells. In the M phase, karyokinesis comes FIRST and cytokinesis comes LAST. Memory hook: "Karyo = Karyon = nucleus first, Cyto = cytoplasm splits last."
Karyokinesis (nucleus divides) then Cytokinesis (cell divides)1 nucleusParent cellKaryokinesis2 nuclei, 1 cellCytokinesis2 separate cells
Karyokinesis divides the nucleus first (two nuclei in one cell); cytokinesis then divides the cytoplasm to give two separate daughter cells.

Your doubts, answered

Which comes first, karyokinesis or cytokinesis?

Karyokinesis comes first. The M phase starts with nuclear division (karyokinesis), where daughter chromosomes separate, and it usually ends with cytoplasm division (cytokinesis). So the order is: karyokinesis then cytokinesis. NEET 2024 tested exactly this order, so never reverse the two.

Is karyokinesis the same as mitosis?

No. Karyokinesis is only the nuclear division part. Mitosis (M phase) = karyokinesis + cytokinesis. Karyokinesis itself is divided into 4 stages: prophase, metaphase, anaphase and telophase. Cytokinesis is a separate step that divides the cytoplasm after karyokinesis.

What happens if cytokinesis does not occur after karyokinesis?

If the nucleus divides (karyokinesis) but the cytoplasm does not divide (no cytokinesis), you get more than one nucleus inside a single cell. This multinucleate condition is called a syncytium. NCERT's example is the liquid endosperm of coconut. If a whole extra chromosome set stays in one cell, it can cause polyploidy (NEET 2016).

Does cytokinesis mean the nucleus divides?

No, that is a common mistake. Cytokinesis divides the CYTOPLASM, not the nucleus. The nucleus is already divided during karyokinesis. Cytokinesis just physically splits the cell body into two.

How is cytokinesis different in plant cells and animal cells?

In animal cells, cytokinesis happens by a furrow (a pinch) in the plasma membrane that deepens inward until the cell splits. In plant cells, the rigid cell wall cannot pinch, so a cell-plate forms in the CENTRE and grows outward to meet the side walls. This cell-plate becomes the middle lamella. Karyokinesis is the same in both.

⚠️ The NEET trap
Cytokinesis happens first and karyokinesis happens later.
Karyokinesis (nuclear division) happens first; cytokinesis (cytoplasm division) happens last. Order: G1 -> S -> G2 -> karyokinesis -> cytokinesis.
🧠 NEET 2024 gave the stages jumbled and reversed karyokinesis and cytokinesis in the wrong options. Karyon = nucleus = comes first.

Real NEET questions

2024

Following are the stages of cell division: A. Gap 2 phase B. Cytokinesis C. Synthesis phase D. Karyokinesis E. Gap 1 phase. Choose the correct sequence of stages from the options given below:

A · E-B-D-A-C
B · B-D-E-A-C
C · E-C-A-D-B
D · C-E-D-A-B
Solution: Interphase runs G1 (E) -> S (C) -> G2 (A), then M phase begins with karyokinesis (D, nuclear division) and ends with cytokinesis (B, cytoplasm division). So the order is E-C-A-D-B. Wrong options either misplace the S phase or reverse karyokinesis and cytokinesis.
2016

A cell at telophase is observed in a plant from the field. There is no formation of cell plate and the cell contains more chromosomes than other dividing cells. This would result in:

A · Aneuploidy
B · Polyploidy
C · Somaclonal variation
D · Polyteny
Solution: If the cell-plate (cytokinesis) fails to form at telophase, karyokinesis is not followed by cytoplasm division, so both chromosome sets stay in one cell, giving a whole extra set = polyploidy. Aneuploidy is gain/loss of single chromosomes, not whole sets.

Solved Cell Cycle and Cell Division NEET PYQs

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Frequently asked

What is karyokinesis in one line?

Karyokinesis is the division of the nucleus, in which the duplicated chromosomes separate into two equal daughter nuclei.

What is cytokinesis in one line?

Cytokinesis is the division of the cytoplasm that splits one cell into two daughter cells, completing cell division.

Which is nuclear division and which is cytoplasm division?

Karyokinesis = nuclear (karyon = nucleus) division. Cytokinesis = cytoplasm (cyto = cell body) division.

Can karyokinesis happen without cytokinesis?

Yes. When karyokinesis is not followed by cytokinesis, a multinucleate cell called a syncytium forms, for example the liquid endosperm of coconut.

Is cytokinesis part of mitosis?

Yes. The M phase includes both karyokinesis (the four stages: prophase, metaphase, anaphase, telophase) and cytokinesis at the end.