Why Posterior Pituitary is Not a True Endocrine Gland

Biology · Chemical Coordination and Integration · NEET

The posterior pituitary (neurohypophysis / pars nervosa) is NOT a true endocrine gland because it does not make any hormone of its own. It only stores and releases two hormones, oxytocin and vasopressin (ADH), which are actually made by the hypothalamus and sent down nerve fibres to the posterior pituitary. Memory hook: "Posterior = Postman" — it only delivers hormones, it does not manufacture them.
Hormones are MADE in hypothalamus, only STORED in posterior pituitaryHYPOTHALAMUSmakes oxytocinmakes vasopressin(ADH)axonal transport (nerve fibres)POSTERIOR PITUITARY(neurohypophysis) STORES + RELEASESBLOODto targetsNo synthesis here = NOT a true endocrine gland
Oxytocin and vasopressin (ADH) are synthesised in the hypothalamus, carried by axonal transport to the posterior pituitary, which only stores and releases them into the blood. Because it makes no hormone of its own, the posterior pituitary is not a true endocrine gland.

Your doubts, answered

Does the posterior pituitary make any hormone by itself?

No. This is the whole point. The posterior pituitary (neurohypophysis) makes zero hormones of its own. Oxytocin and vasopressin (ADH) are synthesised in the hypothalamus. They travel down the axons (nerve fibres) into the posterior pituitary, where they are stored and later released into the blood. So it acts only as a storage and release site.

Then why is it still counted as part of the endocrine system?

Because hormones ARE released into the blood from it. It is a release point for two real hormones, so functionally it is part of the endocrine system. But a 'true' endocrine gland must SYNTHESISE its own hormone. Since the posterior pituitary only stores what the hypothalamus made, NCERT calls it a store-and-release structure, not a true gland.

How is the anterior pituitary different from the posterior pituitary?

The anterior pituitary (adenohypophysis / pars distalis) is a TRUE endocrine gland — it makes its own six hormones: GH, PRL, TSH, ACTH, LH and FSH. The posterior pituitary (neurohypophysis / pars nervosa) makes none; it only stores and releases oxytocin and vasopressin made by the hypothalamus. Anterior = maker, posterior = storekeeper.

How do the hormones reach the posterior pituitary from the hypothalamus?

They travel by axonal transport. The hypothalamic neurons that make oxytocin and vasopressin have long axons that run down the stalk into the posterior pituitary. The hormones move along these nerve fibres (not through blood) and are stored at the nerve endings. NCERT states they are 'transported axonally to neurohypophysis'.

Is the anterior pituitary hormone delivery also axonal?

No — this is a common mix-up. The hypothalamus controls the ANTERIOR pituitary through a blood link called the hypophyseal portal system, using releasing and inhibiting hormones. It controls the POSTERIOR pituitary through a nerve (axonal) link. Blood route for anterior, nerve route for posterior.

⚠️ The NEET trap
Posterior pituitary synthesises and secretes oxytocin and vasopressin.
Posterior pituitary only STORES and RELEASES oxytocin and vasopressin; they are SYNTHESISED by the hypothalamus.
🧠 NTA loves the verb. 'Synthesises' or 'produces' for posterior pituitary is the trap word — it only 'stores and releases'. Read the verb carefully.

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Frequently asked

What is the other name of the posterior pituitary?

It is called the neurohypophysis or pars nervosa. 'Neuro' points to its nerve (axonal) connection with the hypothalamus.

Which two hormones are released by the posterior pituitary?

Oxytocin and vasopressin (also called antidiuretic hormone, ADH). Both are made by the hypothalamus and only stored and released here.

Which part of the pituitary is a true endocrine gland?

The anterior pituitary (adenohypophysis / pars distalis) is the true endocrine gland because it synthesises its own hormones: GH, PRL, TSH, ACTH, LH and FSH.

Why is vasopressin called ADH?

Vasopressin acts on the kidney and increases resorption of water by the distal tubules, reducing water loss in urine (diuresis). Because it works against diuresis, it is called anti-diuretic hormone (ADH).

Is the pineal gland also not a true gland like the posterior pituitary?

No. The pineal gland is a true endocrine gland — it synthesises its own hormone, melatonin. Only the posterior pituitary is the store-and-release exception among the pituitary parts.