What is DNA? Molecular Basis of Inheritance Explained Simply

Biology · Molecular Basis of Inheritance · NEET

DNA stands for Deoxyribonucleic Acid. It is a long polymer (long chain) made of many small units called deoxyribonucleotides, and it acts as the genetic material in most living organisms. Memory hook: think "D-N-A = Data of Nature's Actions" - it stores all the instructions to build and run a body.
What is DNA? DNA = Deoxyribonucleic AcidDNA (long polymer)made of manydeoxyribonucleotides= genetic materialin MOST organisms1 unit1 DeoxyribonucleotideBaseSugarPO4sugar = deoxyriboseLength (NCERT)phi X174: 5386 ntE. coli: 4.6x10^6 bpHuman: 3.3x10^9 bp(haploid content)
DNA is a long polymer built from deoxyribonucleotide units. Each unit has a nitrogenous base, a deoxyribose sugar and a phosphate. DNA length is measured in nucleotides or base pairs and is a characteristic of each organism (NCERT values shown).

Your doubts, answered

What is DNA in very simple words?

DNA is a very long chain built from small repeating units. Each small unit is called a deoxyribonucleotide. So DNA is a long polymer of deoxyribonucleotides. It carries the instructions (genetic information) that decide the features of an organism, so NCERT calls it the genetic material of most organisms.

What is the full form of DNA?

DNA stands for Deoxyribonucleic Acid. The name tells you two things NEET loves to test: 'Deoxyribo' means its sugar is deoxyribose (ribose sugar missing one oxygen at the 2' position), and 'nucleic acid' means it is one of the two nucleic acids in living systems, the other being RNA (Ribonucleic Acid).

Is DNA the genetic material in every organism?

No. This is a common trap. NCERT says DNA acts as the genetic material in MOST organisms, not all. In some viruses, RNA is the genetic material (for example, TMV and some bacteriophages). So the safe NEET answer is: DNA is the genetic material in most organisms, RNA in a few viruses.

What is the difference between DNA and a gene?

DNA is the whole long molecule. A gene is only a small functional segment of that DNA that codes for a product (like a protein). One long DNA molecule contains many genes. So every gene is made of DNA, but the full DNA is much more than a single gene.

How is the length of DNA measured?

The length of DNA is defined as the number of nucleotides, or the number of base pairs (bp), present in it. This number is a characteristic of the organism. NCERT examples you must remember: bacteriophage phi X174 has 5386 nucleotides, E. coli has 4.6 x 10^6 bp, and haploid human DNA has 3.3 x 10^9 bp.

What is DNA chemically made of?

DNA is made of deoxyribonucleotides. Each deoxyribonucleotide has three parts: a nitrogenous base (Adenine, Guanine, Cytosine or Thymine), a sugar called deoxyribose, and a phosphate group. Because the sugar is deoxyribose (not ribose), the molecule is called Deoxyribonucleic Acid.

⚠️ The NEET trap
The sugar in DNA is ribose, so DNA and RNA have the same sugar.
The sugar in DNA is 2'-deoxyribose, while the sugar in RNA is ribose. Deoxyribose is ribose with one oxygen removed at the 2' position (2'-OH becomes 2'-H). This single missing oxygen is exactly why the acid is named DEOXYribonucleic acid.
🧠 'Deoxy' literally means 'oxygen removed'. If you remember the name, you already remember the answer: DNA = deoxyribose, RNA = ribose.

Real NEET questions

2016

The correct statement regarding RNA and DNA, respectively is:

A · The sugar component in RNA is arabinose and the sugar component in DNA is 2'-deoxyribose.
B · The sugar component in RNA is ribose and the sugar component in DNA is 2'-deoxyribose.
C · The sugar component in RNA is arabinose and the sugar component in DNA is ribose.
D · The sugar component in RNA is 2'-deoxyribose and the sugar component in DNA is arabinose.
Solution: Both DNA and RNA contain a pentose (5-carbon) sugar. RNA has ribose and DNA has 2'-deoxyribose. Deoxyribose is ribose missing the oxygen at the 2' position (2'-OH in ribose becomes 2'-H in deoxyribose). This is the chemical reason DNA is named Deoxyribonucleic Acid. Arabinose is not found in either, so options A, C and D are wrong.
2016

A molecule that can act as a genetic material must fulfill the traits given below, except

A · It should be able to express itself in the form of 'Mendelian characters'
B · It should be able to generate its replica
C · It should be unstable structurally and chemically
D · It should provide the scope for slow changes that are required for evolution
Solution: NCERT lists the properties a genetic material must have: it should replicate, be chemically and structurally STABLE, allow slow mutational changes for evolution, and express itself as Mendelian characters. 'Unstable structurally and chemically' is the opposite of the required stability, so it is the exception. DNA satisfies these traits better than RNA, which is why DNA is the preferred genetic material in most organisms.

Solved Molecular Basis of Inheritance NEET PYQs

Try the real previous-year questions from this chapter — each with the answer and a full solution.

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Frequently asked

Who discovered that DNA is the genetic material?

The idea built up over several experiments. Griffith showed the 'transforming principle', Avery, MacLeod and McCarty showed the transforming principle was DNA, and Hershey and Chase (1952) gave the unequivocal (final) proof that DNA is the genetic material using bacteriophages labelled with radioactive 32P and 35S.

Why is DNA called a polymer?

A polymer is a long molecule made by joining many small repeating units called monomers. In DNA, the monomers are deoxyribonucleotides. Thousands to billions of these are linked together, so DNA is correctly called a long polymer of deoxyribonucleotides.

What is the length of human DNA in base pairs?

The haploid content of human DNA is 3.3 x 10^9 base pairs. Using 0.34 nm per base pair, this stretches to about 2 metres of DNA packed inside a single tiny nucleus, which is a famous NEET calculation.

Is DNA the same as a chromosome?

No. DNA is the molecule that carries genetic information. A chromosome is DNA packaged tightly with proteins (histones) so that a very long DNA molecule fits inside the nucleus. So a chromosome is basically highly folded DNA plus protein.

What are the two types of nucleic acids?

The two nucleic acids found in living systems are DNA (Deoxyribonucleic Acid) and RNA (Ribonucleic Acid). DNA is the genetic material in most organisms, while RNA mostly acts as a messenger, adapter, structural and sometimes catalytic molecule, and is the genetic material only in some viruses.