NEET 2016 Phase 2 · BiologyAmino acids/proteinsPrevious Year Question
Which of the following is the least likely to be involved in stabilizing the three-dimensional folding of most proteins?
Answer: (D) Ester bonds. Answer: (D) Ester bonds.
- A.Hydrogen bonds
- B.Electrostatic interaction
- C.Hydrophobic interaction
- D.Ester bonds✓
Correct Answer
(D) Ester bonds
Solution & Explanation
Answer: (D) Ester bonds. Solution: The three-dimensional (tertiary) folding of proteins is stabilised by weak interactions among R-groups — hydrogen bonds, electrostatic (ionic) interactions and hydrophobic interactions (plus disulphide bridges). Ester bonds are not a feature of protein folding (they link fatty acids to glycerol in lipids and the sugar-phosphate backbone of nucleic acids), so they are least likely to stabilise protein 3-D structure. NCERT Reference: Ch 9, p.112, line ~42 — "secondary and the tertiary structure. When you look at a tertiary structure"
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