Transplantation of tissues/organs fails often due to non-acceptance by the patient's body. Which type of immune-response is responsible for such rejections?
Answer: (B) Cell-mediated immune response. Answer: (B) Cell-mediated immune response Solution: NCERT states that the body differentiates 'self' and 'nonself', and the cell-mediated immune response (mediated by T-lymphocytes) is responsible for graft rejection.
- A.Autoimmune response
- B.Cell-mediated immune response✓
- C.Hormonal immune response
- D.Physiological immune response
Correct Answer
(B) Cell-mediated immune response
Solution & Explanation
Answer: (B) Cell-mediated immune response Solution: NCERT states that the body differentiates 'self' and 'nonself', and the cell-mediated immune response (mediated by T-lymphocytes) is responsible for graft rejection. This is why tissue and blood-group matching are required and immunosuppressants are taken after transplant. Why not the others: Autoimmune response is the attack on one's OWN cells, not a graft; there is no 'hormonal' or 'physiological' immune response category for rejection (physiological barriers belong to innate immunity). NCERT Reference: NCERT Ch7, p.136, lines 7-9: "the cell-mediated immune response is responsible for the graft rejection"