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NEET 2019 · BiologyPrevious Year Question

Which of the following immune responses is responsible for rejection of kidney graft?

Answer: (D) Cell-mediated immune response. Answer: (D) Cell-mediated immune response Solution: Graft/transplant rejection occurs because the body distinguishes 'self' from 'nonself', and the cell-mediated immune response (mediated by T-lymphocytes) is responsible for rejecting the graft.

  1. A.Auto-immune response
  2. B.Humoral immune response
  3. C.Inflammatory immune response
  4. D.Cell-mediated immune response✓

Correct Answer

(D) Cell-mediated immune response

Solution & Explanation

Answer: (D) Cell-mediated immune response Solution: Graft/transplant rejection occurs because the body distinguishes 'self' from 'nonself', and the cell-mediated immune response (mediated by T-lymphocytes) is responsible for rejecting the graft. This is why tissue and blood-group matching plus lifelong immunosuppressants are needed. Why others are wrong: Humoral (antibody-mediated) response acts against free antigens, not transplanted tissue; auto-immune and inflammatory responses are unrelated to graft rejection. NCERT Reference: NCERT Ch7, p.136, lines 7-9: "the cell-mediated immune response is responsible for the graft rejection"

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