With regard to insulin choose correct options. (a) C-peptide is not present in mature insulin. (b) The insulin produced by rDNA technology has C-peptide. (c) The pro-insulin has C-peptide. (d) A-peptide and B-peptide of insulin are interconnected by disulphide bridges Choose the correct answer from the options given below. (NEET 2021)
Answer: (A) (a), (c) and (d) only. Answer: (A) (a), (c) and (d) only Solution: Insulin is synthesised as a pro-hormone (pro-insulin) containing an extra C-peptide, so statement (c) is true.
- A.(a), (c) and (d) only✓
- B.(a) and (d) only
- C.(b) and (d) only
- D.(b) and (c) only
Correct Answer
(A) (a), (c) and (d) only
Solution & Explanation
Answer: (A) (a), (c) and (d) only Solution: Insulin is synthesised as a pro-hormone (pro-insulin) containing an extra C-peptide, so statement (c) is true. This C-peptide is removed during maturation and is absent in mature insulin, so (a) is true. The two chains A and B are linked by disulphide bridges, so (d) is true. Statement (b) is false — rDNA insulin is assembled directly from separate A and B chains and has no C-peptide. Hence (a), (c) and (d). NCERT Reference: Ch 10, p.182, line 6 — "This C peptide is not present in the mature insulin and is removed during maturation into insulin"