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NEET 2023 Phase 2 · BiologyPrevious Year Question

Select incorrect statement, regarding chemical structure of insulin.

Answer: (C) Mature insulin molecule consists of three polypeptide chains - A, B and C.. Answer: (c) Mature insulin molecule consists of three polypeptide chains - A, B and C.

  1. A.C-peptide is not present in mature insulin molecule.
  2. B.Polypeptide chains A and B are linked by disulphide bridges.
  3. C.Mature insulin molecule consists of three polypeptide chains - A, B and C.✓
  4. D.Insulin is synthesized as prohormone which contains extra stretch of C-peptide.

Correct Answer

(C) Mature insulin molecule consists of three polypeptide chains - A, B and C.

Solution & Explanation

Answer: (c) Mature insulin molecule consists of three polypeptide chains - A, B and C. Solution: This statement is INCORRECT: mature insulin has only two polypeptide chains (A and B) linked by disulphide bridges, not three. The C-peptide is part of the proinsulin (prohormone) stretch and is cleaved off during maturation, so it is absent in mature insulin — making the other statements correct. NCERT Reference: Chapter 19, Page 245, Line(s) 42-43 — "Insulin is a peptide hormone, which plays a major role in the regulation of glucose homeostasis."

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