Class 11 · Biomolecules

Macromolecules and Micromolecules — NEET Biology

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The acid insoluble fraction, has only four types of organic compounds i.e., proteins, nucleic acids, polysaccharides and lipids. These classes of compounds with the exception of lipids, have molecular weights in the range of ten thousand daltons and above. For this very reason, biomolecules, i.e., chemical compounds found in living organisms are of two types. One, those which have molecular weights less than one thousand dalton and are usually referred to as micromolecules or simply biomolecules while those which are found in the acid insoluble fraction are called macromolecules or biomacromolecules.

NCERT Biology · Class 11 · Chapter 9 · Paragraph 13
How NTA Uses This Concept

NEET tests your understanding of biomolecule classification based on molecular weight. The acid-insoluble fraction contains only four organic compounds: proteins, nucleic acids, polysaccharides, and lipids. Molecules under 1000 daltons are micromolecules; those above 10,000 daltons (except lipids) are macromolecules. Students often confuse lipids with macromolecules because they appear in the acid-insoluble fraction—remember, lipids have lower molecular weights despite being acid-insoluble. The key to avoiding mistakes: memorize the 1000 and 10,000 dalton cutoffs, and note that lipids are the exception to the macromolecule rule. This concept is fundamental to understanding biochemistry and appears frequently in comparative questions.

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QuestionNEET 2026 (cancelled)

Identify the correct statements about biomolecules. A. Lipids are generally water soluble. B. Proteins are polypeptides. C. Polysaccharides are long chains of sugars. D. Adenine and guanine are substituted pyrimidines. E. Almost all enzymes are proteins.

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