What is DNA fingerprinting? Mention its application.
Which of the following statements regarding Variable Number of Tandem Repeats (VNTRs) and their application in DNA fingerprinting are correct? S1: VNTRs are non-coding, highly polymorphic repetitive DNA sequences that constitute the fundamental basis of DNA fingerprinting. S2: The copy number of VNTRs is consistent across all chromosomes within an individual, leading to a unique pattern between individuals. S3: DNA fingerprinting employing VNTRs can typically distinguish between monozygotic twins due to unique individual-specific variations. S4: Polymorphism in VNTRs refers to variations in the length of the tandem repeat units, which directly results in differing band sizes during autoradiography. S5: VNTRs are a class of micro-satellites and form major peaks distinct from bulk genomic DNA during density gradient centrifugation.
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