Class 12 · Molecular Basis of Inheritance

Nucleosome Count in Mammalian Cells — NEET Biology

🔥 Predicted for NEET 2027
📖 NCERT Source

Theoretically, how many such beads (nucleosomes) do you imagine are present in a mammalian cell?

NCERT Biology · Class 12 · Chapter 5 · Paragraph 21
Why This May Be Tested in NEET 2027

Adjacent to a frequently-asked paragraph in the same chapter.

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QuestionPredicted for NEET 2027

Arrange the following events in the correct sequence of DNA helix packaging inside a eukaryotic cell: 1. Formation of chromatin fibres from beads-on-string structure 2. DNA wraps around histone octamer to form nucleosome (200 bp each) 3. Condensation of chromatin fibres into chromosomes at metaphase 4. Organisation of nucleosomes into beads-on-string structure under EM 5. Association of DNA with positively charged histones

📖 Solution & NCERT Explanation
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Correct answer: A 5 → 2 → 4 → 1 → 3

DNA (negatively charged) first associates with histones (positively charged). This wrapping around histone octamer creates nucleosomes (200 bp DNA per nucleosome). Nucleosomes appear as beads-on-string under EM. These further coil into chromatin fibres. During metaphase, chromatin fibres are highly condensed to form visible chromosomes.

❓ Frequently Asked Questions
What does NCERT say about Theoretically how many such?
Theoretically, how many such beads (nucleosomes) do you imagine are present in a mammalian cell?
Has this concept appeared in NEET?
High probability for NEET 2027. Adjacent to a frequently-asked paragraph in the same chapter.
Which chapter is this from?
Molecular Basis of Inheritance, Class 12 NCERT Biology.

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