Most Abundant Protein: Collagen vs RuBisCO

Biology · Biomolecules · NEET

Collagen is the most abundant protein in the ANIMAL world. RuBisCO is the most abundant protein in the WHOLE BIOSPHERE (all life on Earth). Memory hook: "Animal = Collagen, Whole Earth = RuBisCO." Both facts come straight from NCERT, and NEET asks them almost every year, so learn both lines exactly.
Most Abundant Protein: Two Different ScopesIn ANIMALSCOLLAGENStructural protein ofskin, bone, tendonIn WHOLE BIOSPHERERuBisCOAlso most abundantenzyme in the world
Scope decides the answer: collagen is the most abundant protein in animals, RuBisCO in the whole biosphere (and it is also the most abundant enzyme in the world).

Your doubts, answered

Which is the most abundant protein in animals?

Collagen. NCERT states plainly: 'Collagen is the most abundant protein in the animal world.' It is a structural protein found in skin, bone, tendons and the space between cells (intercellular ground substance). For NEET, if the question says 'animal', the answer is collagen, NOT RuBisCO.

Which is the most abundant protein in the whole biosphere?

RuBisCO (Ribulose bisphosphate Carboxylase-Oxygenase). NCERT says RuBisCO 'is the most abundant protein in the whole of the biosphere' and also 'the most abundant enzyme in the world.' The biosphere means all living things on Earth. Because green plants cover the planet and every chloroplast is full of RuBisCO, this one enzyme wins the whole-Earth count.

So is collagen or RuBisCO the most abundant protein? Which answer is correct?

Both are correct, but for DIFFERENT scopes. Read the question word carefully. 'Most abundant in ANIMALS' = collagen. 'Most abundant in the BIOSPHERE / world / whole Earth' = RuBisCO. NEET sets traps by mixing these two, so the scope word decides the answer.

Is RuBisCO a protein or an enzyme?

It is both. All enzymes (except ribozymes) are proteins. RuBisCO is an enzyme of the Calvin cycle that fixes CO2 onto RuBP. Because it is a protein, it can also hold the title 'most abundant protein in the biosphere' and 'most abundant enzyme in the world' at the same time.

Is collagen the most abundant protein in the human body?

Yes. Collagen is the most abundant protein in the human body and in animals in general. It gives strength to skin, bones, cartilage and tendons. NCERT frames it as the most abundant protein in the 'animal world', which includes humans, so treat 'human body' the same as 'animals' here.

What does RuBisCO stand for and why is it so abundant?

RuBisCO = Ribulose bisphosphate Carboxylase-Oxygenase. It is abundant because it is the main CO2-fixing enzyme in the leaves of every green plant on Earth, and plant life is huge in total mass. Its active site can bind both CO2 and O2, which is why its name has both 'carboxylase' and 'oxygenase'.

⚠️ The NEET trap
Picking RuBisCO when the question asks for the most abundant protein in ANIMALS (or picking haemoglobin because it feels famous).
Collagen is the most abundant protein in animals. RuBisCO is most abundant only in the whole biosphere. Match the answer to the scope word in the question.
🧠 Animal → Collagen. Biosphere/World → RuBisCO. The scope word is the answer key.

Real NEET questions

NEET 2020

Which one of the following is the most abundant protein in the animals?

A · Lectin
B · Insulin
C · Haemoglobin
D · Collagen
Solution: NCERT states plainly that collagen is the most abundant protein in the animal world, while RuBisCO is the most abundant protein in the whole biosphere. Insulin and haemoglobin are important but far less abundant, and lectins are minor proteins. So the answer is collagen. Trap: the word 'animals' rules out RuBisCO.
NEET 2023 Phase 2

Given below are two statements: Statement I: RuBisCO is the most abundant enzyme in the world. Statement II: Photorespiration does not occur in C4 plants. In the light of the above statements, choose the most appropriate answer.

A · Both Statement I and Statement II are correct
B · Both Statement I and Statement II are incorrect
C · Statement I is correct but Statement II is incorrect
D · Statement I is incorrect but Statement II is correct
Solution: Statement I is a direct NCERT fact: RuBisCO is the most abundant protein/enzyme in the whole biosphere. Statement II is also correct: C4 plants concentrate CO2 at the RuBisCO site in bundle sheath cells, so photorespiration does not occur. Hence both statements are correct.

Solved Biomolecules NEET PYQs

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Frequently asked

What is the most abundant protein in the biosphere?

RuBisCO (Ribulose bisphosphate Carboxylase-Oxygenase). It is the CO2-fixing enzyme of photosynthesis and is present in huge amounts in all green plants, so it is the most abundant protein in the whole biosphere.

What is the most abundant protein in animals?

Collagen. It is a structural protein of skin, bone, cartilage and tendons, and NCERT names it the most abundant protein in the animal world and the intercellular ground substance.

Can one protein be both an enzyme and the most abundant protein?

Yes. RuBisCO is an enzyme (Calvin cycle) and also a protein, so it holds both titles: 'most abundant enzyme in the world' and 'most abundant protein in the biosphere.'

Is haemoglobin the most abundant protein?

No. Haemoglobin is important for oxygen transport but is not the most abundant. Collagen is most abundant in animals; RuBisCO is most abundant in the biosphere.

How do I avoid the NEET trap between collagen and RuBisCO?

Read the scope word. 'Animal' or 'human body' means collagen. 'Biosphere', 'world', or 'whole Earth' means RuBisCO. The word chooses the answer.