NEET 2024 · BiologyEnzymesPrevious Year Question
Inhibition of Succinic dehydrogenase enzyme by malonate is a classical example of
Answer: (B) Competitive inhibition. Answer: (B) Competitive inhibition.
- A.Feedback inhibition
- B.Competitive inhibition✓
- C.Enzyme activation
- D.Cofactor inhibition
Correct Answer
(B) Competitive inhibition
Solution & Explanation
Answer: (B) Competitive inhibition. Solution: Malonate closely resembles the substrate succinate in molecular structure and competes with it for the substrate-binding site of succinic dehydrogenase; this is the textbook example of competitive inhibition, not feedback inhibition, activation or cofactor inhibition. NCERT Reference: Ch 9, p.117, line ~10 — "inhibition of succinic dehydrogenase by malonate which closely resembles the substrate succinate in structure."
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