Adrenaline and Noradrenaline: The Emergency Hormones

Biology · Chemical Coordination and Integration · NEET

Adrenaline (epinephrine) and noradrenaline (norepinephrine) are two hormones made by the adrenal medulla, the inner part of the adrenal gland. They are called catecholamines and are the "emergency hormones" or "fight or flight" hormones because your body releases them fast during stress, fear, or danger. Memory hook: think of a scared cat that PADS away fast, P-A-D-S = Pupil dilation, Alertness, Dilated airways, Sugar up (blood glucose rises).
Adrenal Gland: Medulla makes the Emergency HormonesAdrenal Cortex(corticoids)MedullaAdrenaline + Noradrenaline= Catecholamines (amino-acid derived)Fight or Flight: heart rate up, contraction up,breathing up, pupils dilate, piloerection, sweat,glycogen breakdown, blood sugar up (hyperglycemic)
The adrenal medulla (inner tissue) secretes adrenaline and noradrenaline, together called catecholamines. They trigger the fight-or-flight response: faster and stronger heartbeat, faster breathing, pupil dilation, piloerection, sweating, and raised blood sugar. The outer cortex makes different hormones (corticoids).

Your doubts, answered

Is adrenaline made in the adrenal cortex or the adrenal medulla?

Adrenaline and noradrenaline are made in the adrenal MEDULLA, the central (inner) tissue of the adrenal gland. The outer adrenal CORTEX makes different hormones called corticoids (glucocorticoids like cortisol and mineralocorticoids like aldosterone). NCERT is very clear: 'The centrally located tissue is called the adrenal medulla, and outside this lies the adrenal cortex.' A common NEET trap says glucocorticoids come from the medulla, which is wrong.

Are adrenaline and epinephrine the same thing?

Yes. Adrenaline = epinephrine, and noradrenaline = norepinephrine. They are just two names for the same molecules. NCERT writes both names: 'adrenaline or epinephrine and noradrenaline or norepinephrine.' Together they are called catecholamines. NEET can use either name in a question, so learn both.

Why are these called emergency hormones or fight-or-flight hormones?

Because they are secreted very quickly in response to stress of any kind and during emergencies. They prepare the body to either fight the danger or run (flight) from it. NCERT: 'Adrenaline and noradrenaline are rapidly secreted in response to stress of any kind and during emergency situations and are called emergency hormones or hormones of Fight or Flight.'

Does adrenaline raise or lower blood sugar?

It RAISES blood sugar, so it is a hyperglycemic hormone. Catecholamines stimulate the breakdown of glycogen (glycogenolysis), which increases blood glucose. NCERT: 'Catecholamines also stimulate the breakdown of glycogen resulting in an increased concentration of glucose in blood.' This is a very common NEET point and matches the 2025 PYQ.

Does adrenaline cause pupil dilation or constriction?

Adrenaline causes pupil DILATION (widening), not constriction. It also causes increased alertness, piloerection (raising of hairs), and sweating. NCERT lists: 'increase alertness, pupilary dilation, piloerection (raising of hairs), sweating.' NEET 2025 tested exactly this trap: 'pupillary constriction' was the wrong statement.

What effects do adrenaline and noradrenaline have on the heart and breathing?

Both hormones increase the heart beat (heart rate), the strength of heart contraction, and the rate of respiration. This delivers more oxygen and glucose-rich blood to muscles during an emergency. NCERT: 'Both the hormones increase the heart beat, the strength of heart contraction and the rate of respiration.'

Are catecholamines peptide or amino-acid derived hormones?

Catecholamines (adrenaline/epinephrine) are amino-acid derived hormones, made from the amino acid tyrosine. In NCERT's classification by chemical nature, epinephrine is the given example of an amino-acid derivative. This was tested in NEET 2018, where epinephrine was the correct amino-acid derived hormone among steroid options.

⚠️ The NEET trap
Glucocorticoids and adrenaline both come from the adrenal medulla, and adrenaline causes pupil constriction.
Adrenaline and noradrenaline (catecholamines) come from the adrenal MEDULLA. Glucocorticoids come from the adrenal CORTEX. Adrenaline causes pupil DILATION, not constriction, and raises blood sugar.
🧠 Medulla = eMergency catecholamines. Cortex = Corticoids. If a statement mixes these two layers, or says pupil 'constriction', it is the trap answer.

Real NEET questions

2025

Consider the following statements regarding function of adrenal medullary hormones: A. It causes pupillary constriction B. It is a hyperglycemic hormone C. It causes piloerection D. It increases strength of heart contraction. Choose the correct answer from the options given below:

A · A, C and D Only
B · D Only
C · C and D Only
D · B, C and D Only
Solution: Adrenal medullary hormones (catecholamines) are hyperglycemic because they break down glycogen and raise blood glucose (B), cause piloerection or raising of hairs (C), and increase the strength of heart contraction (D). They cause pupillary DILATION, not constriction, so statement A is wrong. Hence B, C and D are correct, which is the 4th option.
2018

Which of the following is an amino acid derived hormone?

A · Estradiol
B · Ecdysone
C · Epinephrine
D · Estriol
Solution: By chemical nature, NCERT lists epinephrine (adrenaline) as the example of an amino-acid derivative. Estradiol and estriol are steroid hormones and ecdysone is an insect steroid. So only epinephrine is amino-acid derived.
2023

Which of the following statements are correct with respect to the hormone and its function? (A) Thyrocalcitonin (TCT) regulates the blood calcium level. (B) In males, FSH and androgens regulate spermatogenesis. (C) Hyperthyroidism can lead to goitre. (D) Glucocorticoids are secreted in Adrenal Medulla. (E) Parathyroid hormone is regulated by circulating levels of sodium ions.

A · (B) and (C) only
B · (A) and (D) only
C · (C) and (E) only
D · (A) and (B) only
Solution: TCT regulates blood calcium (A correct) and FSH plus androgens regulate spermatogenesis in males (B correct). Statement D is the trap: glucocorticoids come from the adrenal CORTEX, not the medulla. So (A) and (B) only is correct.

Solved Chemical Coordination and Integration NEET PYQs

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Frequently asked

What are catecholamines?

Catecholamines are the common name for adrenaline (epinephrine) and noradrenaline (norepinephrine), the two hormones secreted by the adrenal medulla. They are amino-acid derived hormones made from tyrosine.

Which gland secretes the emergency hormones?

The adrenal medulla, the central part of the adrenal gland sitting on top of each kidney, secretes adrenaline and noradrenaline. There is one pair of adrenal glands, one above each kidney.

List the main actions of adrenaline for NEET.

Increased alertness, pupil dilation, piloerection (raising of hairs), sweating, faster heart beat, stronger heart contraction, faster breathing, and glycogen breakdown that raises blood glucose (hyperglycemic).

Is adrenaline a peptide or steroid hormone?

Neither. Adrenaline is an amino-acid derived hormone (made from tyrosine). It is water soluble and acts through membrane receptors, unlike steroid hormones that enter cells.

How is adrenaline linked to nicotine and smoking?

NCERT notes that nicotine in tobacco stimulates the adrenal gland to release adrenaline and noradrenaline into the blood, which raise blood pressure and increase heart rate. This is why smoking affects the cardiovascular system.