Action Potential: Generation and Depolarisation

Biology · Neural Control and Coordination · NEET

An action potential is generated when a stimulus makes one point on the polarised axon membrane suddenly permeable to Na+. Na+ rushes into the axon, so the inside becomes positive and the outside becomes negative. This reversal of charge is called depolarisation, and this new potential is the action potential, also called the nerve impulse. Memory hook: "Stimulus opens the Na+ gate, Na+ rushes in, polarity flips."
Generation of Action Potential on the Axon MembraneSite A (depolarised)Outer: - - - -Inner: + + + +Site B (resting)Outer: + + + +Inner: - - - -StimulusNa+ influxlocal current A to BImpulse moves A to B, then B to C, along the axon
At the stimulated point (Site A) Na+ rushes in, so the inner side turns positive and the outer side turns negative. This reversed charge is the action potential. A local current then depolarises the next point (Site B), so the impulse travels along the axon.

Your doubts, answered

Is an action potential the same thing as a nerve impulse?

Yes. NCERT clearly says the electrical potential difference across the membrane at the stimulated site is called the action potential, "which is in fact termed as a nerve impulse." So the two words mean the same event. NEET can ask this directly, so remember: action potential = nerve impulse.

What exactly causes depolarisation?

When a stimulus hits a point on the membrane, that point becomes freely permeable to Na+. Sodium ions rush in (influx). Because so many positive Na+ ions enter, the inner side turns positive and the outer side turns negative. This flip of charge is depolarisation.

In an action potential, is the inside of the axon positive or negative?

During the action potential the inside becomes positive and the outside becomes negative. This is the opposite of the resting state. At rest the outer surface is positive and inner surface is negative. So depolarisation reverses the polarity.

Why does Na+ move into the axon and not out?

At rest the axoplasm has low Na+ and the outside fluid has high Na+, so a concentration gradient exists. The moment the Na+ channels open, Na+ moves down this gradient, from high outside to low inside. No energy is needed for this influx; the gradient does the work.

How does the impulse move to the next point on the axon?

At site A the polarity is reversed, but the next point (site B) is still resting. A local current flows between A and B. This current makes site B permeable to Na+, so B also depolarises and generates its own action potential. The sequence repeats along the axon, and this is how the impulse is conducted.

Why does the action potential last only a very short time?

The rise in Na+ permeability is extremely short-lived. It is quickly followed by a rise in K+ permeability. K+ diffuses out and restores the resting potential (repolarisation), making the fibre ready for the next stimulus within a fraction of a second.

⚠️ The NEET trap
During depolarisation the outer surface of the axon becomes positive and the inner surface becomes negative.
During depolarisation the polarity is reversed: the outer surface becomes negative and the inner surface becomes positive because Na+ rushes in.
🧠 Students copy the resting-state charges into the action-potential answer. Remember: depolarisation REVERSES the resting polarity, it does not keep it.

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Frequently asked

What is an action potential in simple words?

It is the reversed electrical charge that appears at a point on the axon membrane when a stimulus makes it permeable to Na+. It is the same as the nerve impulse.

Which ion is responsible for generating the action potential?

Sodium (Na+). Its rapid influx into the axon causes depolarisation and generates the action potential.

What is depolarisation?

Depolarisation is the reversal of the membrane's resting polarity. The inner side becomes positive and the outer side becomes negative because of Na+ influx.

What happens right after depolarisation?

K+ permeability rises, K+ diffuses out, and the resting potential is restored. This is repolarisation, which prepares the fibre for the next stimulus.

Why is this important for NEET?

Neural coordination is a high-yield chapter. NEET often tests the direction of Na+ movement, the reversal of polarity, and the fact that action potential equals nerve impulse. One clear diagram usually settles these questions.