Difference Between Resting Potential and Action Potential

Biology · Neural Control and Coordination · NEET

Resting potential is the steady charge across a neuron membrane when it is not sending a signal: the inside is negative, the outside is positive, so the membrane is "polarised". Action potential is the quick change that happens when a stimulus arrives: Na+ rushes in, the charge flips (inside becomes positive), and this reversed charge is the nerve impulse. Memory hook: RESTing = waiting and polarised; ACTION = flipped and firing.

At a glance

State of membranePolarised (charged, at rest)Depolarised (polarity reversed)
Charge inside neuronNegativePositive
Charge outside neuronPositiveNegative
Ion movementNa+ kept mostly outside; membrane not permeable to Na+Membrane becomes freely permeable to Na+; rapid Na+ influx
When it occursWhen no impulse is passing (neuron at rest)When a stimulus is applied at a site on the axon
Also calledResting potentialAction potential / nerve impulse
RecoveryMaintained by ion balance and Na+/K+ pumpK+ moves out to restore resting potential
Resting Potential vs Action PotentialResting Potential (polarised)+ + + + + + + (outside)- - - - - - - (inside)Inside negative, outside positiveNo impulse; Na+ mostly outsideNeuron is at rest, readyAction Potential (depolarised)- - - - - - - (outside)+ + + + + + + (inside)Charge reversed: inside positiveNa+ rushes IN (influx)This reversal = nerve impulse
At resting potential the membrane is polarised (outside +, inside -). When a stimulus opens Na+ channels, Na+ rushes in and the polarity reverses (inside +): this depolarised state is the action potential, or nerve impulse.

Your doubts, answered

Is the resting potential negative or positive? Inside or outside?

At resting potential the OUTER surface of the membrane is positive and the INNER surface is negative. So the inside of the neuron is negatively charged compared to the outside. This charge difference across the resting membrane is called the resting potential. NCERT calls this state polarised.

Does resting potential mean the neuron is switched off?

No. The neuron is very much alive and ready. Resting potential just means no impulse is passing at that moment. The sodium-potassium pump and the ions keep the membrane polarised so the neuron is set to fire the instant a stimulus comes. Think of it as a charged battery waiting, not a dead one.

Which ion is mainly responsible for the action potential?

Sodium (Na+). When a stimulus hits point A on the membrane, that site suddenly becomes freely permeable to Na+. A rapid influx (rush inward) of Na+ flips the charge, making the inside positive and the outside negative. This reversal is the action potential. Potassium (K+) then flows out afterwards to bring the membrane back to resting potential.

Is action potential the same as a nerve impulse?

Yes. NCERT states clearly that the action potential is in fact termed as a nerve impulse. When the polarity at a site reverses due to Na+ influx, that electrical change is the action potential, and it travels along the axon as the nerve impulse.

What does depolarised mean and how is it different from polarised?

Polarised means the two sides of the membrane carry opposite charges in the resting way: outside positive, inside negative (resting potential). Depolarised means that difference is reversed at the stimulated site: outside becomes negative and inside becomes positive because Na+ rushed in. Resting potential = polarised; action potential = depolarised (reversed polarity).

⚠️ The NEET trap
Action potential is generated by the sudden movement of K+ (potassium) into the neuron.
Action potential is generated by the rapid INFLUX of Na+ (sodium) INTO the neuron, which reverses the polarity. K+ moves OUT later to restore the resting potential.
🧠 Na+ IN starts the impulse (action potential); K+ OUT ends it (back to resting). Match the ion to its direction and you will not be trapped.

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Frequently asked

In one line, what is the main difference between resting potential and action potential?

Resting potential is the polarised state of a neuron at rest (inside negative), while action potential is the reversed, depolarised state during a nerve impulse (inside positive due to Na+ influx).

What is the charge inside the neuron during resting potential vs action potential?

During resting potential the inside is negative and outside positive. During action potential the inside becomes positive and outside negative at the stimulated site because Na+ rushes in.

Why is resting potential important for NEET?

NEET repeatedly tests the polarised (resting) versus depolarised (action) states and which ion moves in each. Knowing that Na+ influx creates the action potential and K+ efflux restores resting potential lets you answer statement-based and match-the-column questions correctly.

Does an action potential move backward along the axon?

No. Once a segment has fired it enters a refractory phase, so the action potential moves only forward, never backward. This one-way movement is a common NEET point.

What restores the membrane to resting potential after an action potential?

After depolarisation, K+ rapidly diffuses out of the neuron. This efflux of K+ restores the resting potential of the membrane at that site, making the fibre ready to fire again.