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NEET 2016 Phase 1 · BiologyPrevious Year Question

The two polypeptides of human insulin are linked together by:

Answer: (D) Disulphide bridges. Answer: (d) Disulphide bridges Solution: Insulin is a peptide hormone secreted by the β-cells of the Islets of Langerhans.

  1. A.Hydrogen bonds
  2. B.Phosphodiester bond
  3. C.Covalent bond
  4. D.Disulphide bridges✓

Correct Answer

(D) Disulphide bridges

Solution & Explanation

Answer: (d) Disulphide bridges Solution: Insulin is a peptide hormone secreted by the β-cells of the Islets of Langerhans. The mature hormone consists of two polypeptide chains (A and B) that are held together by covalent disulphide (–S–S–) bridges between cysteine residues, not by mere hydrogen bonds. This linkage gives the functional insulin molecule its stable tertiary structure. NCERT Reference: Chapter 19, Page 245, Line(s) 42-44 — "Insulin is a peptide hormone, which plays a major role in the regulation of glucose homeostasis. Insulin acts mainly on hepatocytes and adipocytes"

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