NEET 2016 Phase 1 · BiologyAmino acids/proteinsPrevious Year Question
The two polypeptides of human insulin are linked together by:
Answer: (D) Disulphide bridges. Answer: (D) Disulphide bridges.
- A.Hydrogen bonds
- B.Phosphodiester bond
- C.Covalent bond
- D.Disulphide bridges✓
Correct Answer
(D) Disulphide bridges
Solution & Explanation
Answer: (D) Disulphide bridges. Solution: Human insulin is made of two polypeptide chains (A and B) that are held together by covalent disulphide (S–S) bridges between cysteine residues, an inter-chain bond of protein structure. Hydrogen bonds (A) only stabilise secondary/tertiary folding weakly, phosphodiester bonds (B) link nucleotides in nucleic acids, and 'covalent bond' (C) is too generic — the specific covalent linkage here is the disulphide bridge. NCERT Reference: Ch 9, p.112, line ~48 — "Disulphide bond"
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