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NEET 2017 · BiologyPrevious Year Question

During DNA replication, Okazaki fragments are used to elongate

Answer: (D) The lagging strand away from the replication fork. Answer: (D) The lagging strand away from the replication fork.

  1. A.The leading strand towards replication fork
  2. B.The lagging strand towards replication fork
  3. C.The leading strand away from replication fork
  4. D.The lagging strand away from the replication fork✓

Correct Answer

(D) The lagging strand away from the replication fork

Solution & Explanation

Answer: (D) The lagging strand away from the replication fork. Solution: On the template with 5'→3' polarity, replication is discontinuous, producing short Okazaki fragments that are later joined by DNA ligase; this discontinuous (lagging) strand is synthesised in the direction away from the replication fork (each fragment grows 5'→3' opposite to fork movement). The term 'Okazaki fragments' is extension content; NCERT describes them as the discontinuously synthesised fragments. NCERT Ch 5, p.90, lines 38-40: "on the other (the template with polarity 5'→3'), it is discontinuous. The discontinuously synthesised fragments are later joined by the enzyme DNA ligase."

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