Which of the following glucose transporters is insulin-dependent?
Answer: (D) GLUT IV. Answer: (d) GLUT IV Solution: Insulin enhances cellular glucose uptake in target cells such as adipocytes and muscle cells by promoting translocation of the GLUT IV transporter to the cell membrane; hence GLUT IV is the insulin-dependent transporter.
- A.GLUT I
- B.GLUT II
- C.GLUT III
- D.GLUT IV✓
Correct Answer
(D) GLUT IV
Solution & Explanation
Answer: (d) GLUT IV Solution: Insulin enhances cellular glucose uptake in target cells such as adipocytes and muscle cells by promoting translocation of the GLUT IV transporter to the cell membrane; hence GLUT IV is the insulin-dependent transporter. GLUT I, II and III mediate insulin-independent (basal/constitutive) glucose transport. This underlies insulin's role in rapid glucose movement from blood into hepatocytes and adipocytes. NCERT Reference: Chapter 19, Page 246, Line(s) 3-5 — "uptake and utilisation. As a result, there is a rapid movement of glucose from blood to hepatocytes and adipocytes resulting in decreased blood glucose levels (hypoglycemia)."