Class 12 · Molecular Basis of Inheritance

DNA as the Transforming Principle — NEET Biology

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They purified biochemicals (proteins, DNA, RNA, etc.) from the heat-killed S cells to see which ones could transform live R cells into S cells. They discovered that DNA alone from S bacteria caused R bacteria to become transformed.

NCERT Biology · Class 12 · Chapter 5 · Paragraph 31
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Which of the following statements are NOT correct regarding the Avery, MacLeod and McCarty experiment? S1: They purified biochemicals from live R cells to identify the transforming principle. S2: Treatment with proteases inhibited the transformation of R cells into S cells. S3: Digestion with DNase prevented the transformation, indicating DNA as the hereditary material. S4: Their experiment definitively showed that RNA was the genetic material. S5: They confirmed Griffith's 'transforming principle' was a protein.

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